Lee Ji-Young, Kim Jin-Ho, La Tae-Yoon, Choi Jin-A
Department of Ophthalmology and Visual Science, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 64 Daeheung-ro, Jung-gu, Daejeon 34943, Korea.
Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Korea.
J Clin Med. 2021 Sep 18;10(18):4231. doi: 10.3390/jcm10184231.
The aim of this study is to investigate the structure-function characteristics and vision-related quality of life (VR-QoL) in uveitic glaucoma (UG) compared with open-angle glaucoma (OAG).
The study included 69 patients with UG and 138 patients with primary open angle glaucoma, normal-tension glaucoma. A 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) was used to evaluate the patients' VR-QoL. The retinal nerve fiber layer thickness (RNFLT) was measured using optical coherence tomography, and the integrated visual field (IVF) was determined using the best location method.
There were no significant differences in the binocular IVF and mean deviation (MD) of the affected eye between the OAG and UG group, whereas the average RNFLT was significant thinner in the OAG group ( = 0.008). The patients with UG showed a significantly lower composite score and five subscales of the VFQ-25, compared with those with OAG ( < 0.05, for all, general linear model). Multivariate linear regression analyses showed that the composite score showed the strongest associations with the whole IVF (β = 1.240, < 0.001) in the OAG group, whereas in the UG group, a significant association was seen only with the inferior VF of the affected eye (β = 0.596, = 0.038).
The eyes with UG exhibited distinctive structure-function characteristics and worse VR-QoL that differentiated them from OAG eyes.
本研究旨在调查葡萄膜炎性青光眼（UG）与开角型青光眼（OAG）相比的结构功能特征及与视力相关的生活质量（VR-QoL）。
该研究纳入了69例葡萄膜炎性青光眼患者和138例原发性开角型青光眼、正常眼压性青光眼患者。使用25项美国国立眼科研究所视觉功能问卷（VFQ-25）评估患者的VR-QoL。采用光学相干断层扫描测量视网膜神经纤维层厚度（RNFLT），并使用最佳定位方法确定综合视野（IVF）。
OAG组和UG组患眼的双眼IVF及平均偏差（MD）无显著差异，而OAG组的平均RNFLT显著更薄（ = 0.008）。与OAG患者相比，UG患者的VFQ-25综合评分及五个子量表得分显著更低（所有均<0.05，一般线性模型）。多变量线性回归分析显示，OAG组中综合评分与整个IVF的相关性最强（β = 1.240，<0.001），而在UG组中，仅与患眼的下方视野有显著相关性（β = 0.596， = 0.038）。
UG患眼表现出独特的结构功能特征及更差的VR-QoL，这使其有别于OAG患眼。
