Fitzpatrick Noel, Guthrie James W
Fitzpatrick Referrals, Eashing, Godalming, Surrey, United Kingdom.
Vet Surg. 2018 Oct;47(7):963-969. doi: 10.1111/vsu.12955. Epub 2018 Sep 21.
To report the clinical application of a hemipelvic and proximal femoral endoprosthesis for limb salvage.
Retrospective case report.
One 5-year-old, neutered female, flat coated retriever with a malignant neoplasia of the left coxofemoral joint.
An invasive soft tissue mass (histiocytic sarcoma) with bone lysis of the femoral head and acetabulum was noted on radiographs, computed tomography (CT), and MRI. Custom-designed hemipelvic and proximal femoral endoprostheses were produced from CT images and manufactured with hydroxyapatite coated surfaces to allow tissue integration. The proximal femoral implant allowed tendon ongrowth and muscle attachment. The pelvic implant was anchored to the ilium and ischium with screws, and the femoral implant was cemented. Chemotherapy consisted of lomustine (CCNU).
No evidence of implant loosening or local/thoracic metastases was noted on radiographs or CT at 6 weeks and at 3, 6, 9, and 12 months after surgery. A neurapraxia resolved 14 weeks postoperatively. Intensive rehabilitation was performed. At 12 months, activity was unrestricted with minimal residual lameness. The dog was euthanized at 14 months for metastatic disease.
Limb salvage with a hemipelvic and proximal femoral endoprosthesis resulted in limb function and survival for 14 months.
Neoplasia involving the bones of the coxofemoral joint traditionally requires hemipelvic resection and pelvic limb amputation. This report provides evidence that limb salvage can result in satisfactory levels of activity.
报告一种半骨盆及股骨近端假体在保肢治疗中的临床应用。
回顾性病例报告。
一只5岁已绝育的雌性平毛寻回犬,左髋关节患有恶性肿瘤。
X线片、计算机断层扫描(CT)和磁共振成像(MRI)显示股骨头和髋臼有侵袭性软组织肿块(组织细胞肉瘤)并伴有骨质溶解。根据CT图像定制设计半骨盆及股骨近端假体,其表面涂有羟基磷灰石以促进组织整合。股骨近端植入物允许肌腱长入并附着肌肉。骨盆植入物通过螺钉固定在髂骨和坐骨上,股骨植入物采用骨水泥固定。化疗药物为洛莫司汀(环己亚硝脲)。
术后6周以及3、6、9和12个月时,X线片或CT检查均未发现植入物松动或局部/胸部转移的迹象。术后14周神经失用症得到缓解。进行了强化康复训练。12个月时,活动不受限,残留跛行轻微。该犬在14个月时因转移性疾病实施安乐死。
采用半骨盆及股骨近端假体进行保肢治疗可使患肢功能维持14个月。
传统上,累及髋关节骨骼的肿瘤需要进行半骨盆切除及骨盆肢体截肢。本报告提供了证据表明保肢治疗可获得令人满意的活动水平。