Hošnjak Lea, Poljak Mario
Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Acta Dermatovenerol Alp Pannonica Adriat. 2018 Sep;27(3):127-136.
A total of 203 reports published between 1982 and 2017 on the association between human papillomaviruses (HPV) and esophageal squamous cell carcinoma (ESCC), originating from 187 studies performed in 32 countries from six continents, were selected and reviewed. The selected studies included a total of 14,788 ESCC cases; the presence of HPV infection was detected in 30.9% of cases (95% CI 30.1-31.6%) and was the highest in regions with the highest incidence of ESCC. Across studies published in the last 6 years, Alphapapillomavirus species were detected in 31.1% of ESCCs (1,464/4,708, 95% CI 29.8-32.4%), of which 73.8% (1,080/1,464, 95% CI 71.5-76.0%) were positive for the presence of HPV16/18. HPV16 was by far the most common HPV type detected, accounting for 21.0% (799.5/3,803, 95% CI 19.8-22.4%) of the total number of ESCC cases investigated. Our results are in line with previously published studies, suggesting the etiological role of HPV in the development of a subset of ESCC cases. Although the association between HPV and esophageal adenocarcinoma (EAC) has been studied to a far lesser extent, some studies also suggest a potential etiological role of HPV in a subset of EAC cases.
我们选取并回顾了1982年至2017年间发表的共203篇关于人乳头瘤病毒（HPV）与食管鳞状细胞癌（ESCC）之间关联的报告，这些报告源自于在六大洲32个国家进行的187项研究。所选研究总共纳入了14788例ESCC病例；其中30.9%（95%置信区间30.1 - 31.6%）的病例检测到HPV感染，且在ESCC发病率最高的地区感染率最高。在过去6年发表的各项研究中，31.1%（1464/4708，95%置信区间29.8 - 32.4%）的ESCC病例检测到α乳头瘤病毒属，其中73.8%（1080/1464，95%置信区间71.5 - 76.0%）的病例HPV16/18呈阳性。HPV16是迄今为止检测到的最常见的HPV类型，占所调查ESCC病例总数的21.0%（799.5/3803，95%置信区间19.8 - 22.4%）。我们的结果与先前发表的研究一致，表明HPV在一部分ESCC病例的发生中具有病因学作用。尽管HPV与食管腺癌（EAC）之间的关联研究程度要小得多，但一些研究也表明HPV在一部分EAC病例中可能具有病因学作用。
