Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, China.
Ann Epidemiol. 2013 Nov;23(11):726-34. doi: 10.1016/j.annepidem.2013.07.002. Epub 2013 Aug 1.
A possible carcinogenic role of human papillomavirus (HPV) has been investigated in esophageal squamous cell carcinoma (ESCC) for nearly 30 years with mixed results. We performed a meta-analysis to assess the prevalence of "high-risk" HPV, HPV-16/18, in this disease. We also evaluated the association between infection with HPV-16/18 and ESCC risk by meta-analysis of case-control studies.
Eligible studies published up to September 30, 2012 were retrieved via both computer searches of MEDLINE and EMBASE and manual review of references. A random-effects model was used to calculate summary prevalence and odds ratios (ORs) and corresponding 95% confidence intervals (CIs).
A total of 5755 cases of ESCC from 68 studies were included in this meta-analysis. Overall, 11.67% (95% CI, 7.74%-16.21%) of ESCC cases harbored HPV-16 and 1.82% (95% CI, 0.90%-2.95%) harbored HPV-18. In addition, meta-analysis of 10 case-control studies showed a significant increase in ESCC risk with HPV-16 infection (summary ORs = 3.55; 95% CIs, 2.05%-6.14%). However, this increased risk in ESCC was not made for HPV-18 infection (summary ORs = 1.25; 95% CIs, 0.46%-3.43%).
This meta-analysis indicated that HPV-16 and -18 can be detected in ESCC. HPV-16, but not HPV-18, is significantly associated with the risk of ESCC. However, it is early to conclude that both types of HPV are involved in esophageal carcinogenesis.
近 30 年来，人们一直在研究人乳头瘤病毒（HPV）在食管鳞状细胞癌（ESCC）中的致癌作用，但结果不一。我们进行了一项荟萃分析，以评估该疾病中“高危”HPV、HPV-16/18 的流行率。我们还通过病例对照研究的荟萃分析评估了 HPV-16/18 感染与 ESCC 风险之间的关联。
通过计算机检索 MEDLINE 和 EMBASE，并手动查阅参考文献，检索截至 2012 年 9 月 30 日发表的符合条件的研究。使用随机效应模型计算汇总流行率和比值比（OR）及其相应的 95%置信区间（CI）。
共有 68 项研究的 5755 例 ESCC 病例纳入本荟萃分析。总体而言，11.67%（95%CI，7.74%-16.21%）的 ESCC 病例携带 HPV-16，1.82%（95%CI，0.90%-2.95%）携带 HPV-18。此外，对 10 项病例对照研究的荟萃分析显示，HPV-16 感染与 ESCC 风险显著增加（汇总 ORs=3.55；95%CI，2.05%-6.14%）。然而，HPV-18 感染并未增加 ESCC 的风险（汇总 ORs=1.25；95%CI，0.46%-3.43%）。
本荟萃分析表明 HPV-16 和-18 可在 ESCC 中检测到。HPV-16 而不是 HPV-18 与 ESCC 的风险显著相关。然而，认为这两种类型的 HPV 都参与食管癌变还为时过早。
