青少年犯罪的发展变化：建模预防干预和与酒精使用相关的 GABRA2 半合子的时变效应
Developmental Change in Adolescent Delinquency: Modeling Time-Varying Effects of a Preventative Intervention and GABRA2 Halpotype Linked to Alcohol Use.
机构信息
Division of Educational Psychology and Methodology, University at Albany, State University of New York, Albany, NY, USA.
Department of Human Development and Family Studies, The Pennsylvania State University, University Park, PA, USA.
出版信息
J Youth Adolesc. 2019 Jan;48(1):71-85. doi: 10.1007/s10964-018-0929-z. Epub 2018 Sep 22.
Better integrating human developmental factors in genomic research is part of a set of next steps for testing gene-by-environment interaction hypotheses. This study adds to this work by extending prior research using time-varying effect modeling (TVEM) to evaluate the longitudinal associations between the PROSPER preventive intervention delivery system, a GABRA2 haplotype linked to alcohol use, and their interaction on adolescent delinquency. Logistic and Poisson analyses on eight waves of data spanning ages 11 to 19 (60% female, 90% Caucasian) showed the intervention reduced delinquency from ages 13 to 16. Moreover, interaction analysis revealed that the effect of the multicomponent intervention was significantly greater for T-allele carriers of the GABRA2 SNP rs279845, but only during the 13 to 16 age period. The results are discussed in terms of adolescent delinquency normativeness, implications for preventive intervention research, and the utility of incorporating development in GxE research.
更好地将人类发育因素整合到基因组研究中，是检验基因-环境相互作用假设的一系列下一步措施的一部分。本研究通过使用时变效应模型（TVEM）来扩展先前的研究，进一步评估了 PROSPER 预防干预传递系统、与酒精使用相关的 GABRA2 单倍型及其对青少年犯罪的相互作用之间的纵向关联，从而为此项工作做出了贡献。对跨越年龄 11 至 19 岁的 8 个时间点的数据（60%为女性，90%为白种人）进行逻辑和泊松分析表明，该干预措施减少了 13 至 16 岁年龄段的犯罪行为。此外，交互分析表明，对于 GABRA2 SNP rs279845 的 T 等位基因携带者，多组分干预的效果显著更大，但仅在 13 至 16 岁年龄期间。本文将从青少年犯罪常态性、预防干预研究的意义以及将发展纳入 GxE 研究的效用等方面讨论这些结果。
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