从儿童期到成年期，GABRG1 和适应不良同伴行为对外显行为的时变效应：检验基因×环境×发展的影响。
Time-varying Effects of GABRG1 and Maladaptive Peer Behavior on Externalizing Behavior from Childhood to Adulthood: Testing Gene × Environment × Development Effects.
机构信息
Psychology Department and the Center for Children and Families, Florida International University, Miami, FL, USA.
Psychiatry Department, University of Michigan, Ann Arbor, MI, USA.
出版信息
J Youth Adolesc. 2020 Jul;49(7):1351-1364. doi: 10.1007/s10964-019-01171-3. Epub 2019 Nov 30.
Engagement in externalizing behavior is problematic. Deviant peer affiliation increases risk for externalizing behavior. Yet, peer effects vary across individuals and may differ across genes. This study determines gene × environment × development interactions as they apply to externalizing behavior from childhood to adulthood. A sample (n = 687; 68% male, 90% White) of youth from the Michigan Longitudinal Study was assessed from ages 10 to 25. Interactions between γ-amino butyric acid type A receptor γ1 subunit (GABRG1; rs7683876, rs13120165) and maladaptive peer behavior on externalizing behavior were examined using time-varying effect modeling. The findings indicate a sequential risk gradient in the influence of maladaptive peer behavior on externalizing behavior depending on the number of G alleles during childhood through adulthood. Individuals with the GG genotype are most vulnerable to maladaptive peer influences, which results in greater externalizing behavior during late childhood through early adulthood.
外化行为的参与存在问题。偏差同伴的关系会增加外化行为的风险。然而，同伴效应因人而异，可能因基因而异。本研究从儿童期到成年期确定了外化行为的基因-环境-发展相互作用。来自密歇根纵向研究的青年样本（n=687；68%为男性，90%为白人）从 10 岁到 25 岁进行了评估。使用时变效应模型，研究了γ-氨基丁酸 A 型受体γ1 亚基（GABRG1；rs7683876，rs13120165）和适应不良同伴行为与外化行为之间的相互作用。研究结果表明，在儿童期到成年期期间，根据 G 等位基因的数量，适应不良同伴行为对外化行为的影响存在连续的风险梯度。具有 GG 基因型的个体最容易受到适应不良同伴的影响，这导致在儿童后期到成年早期的外化行为更多。
Zotero 插件