Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD, 21205, USA.
Division of Educational Psychology and Methodology, University at Albany, SUNY, 1400 Washington Ave., Albany, NY, 12222, USA.
Prev Sci. 2018 Jan;19(1):1-5. doi: 10.1007/s11121-017-0837-6.
With recent advances in high-throughput technology, genetic and other biological data have been increasingly incorporated in social science research, including prevention/intervention studies. Understanding the role genetics play in complex behaviors commonly evaluated in prevention/intervention research may have important implications for designing prevention programing, determining who receives certain prevention programs, and understanding individual differences in programming effectiveness (see Jaffee & Price, 2007; Moffitt, Caspi, & Rutter, 2006). This special issue, seeks to advance work in this area by presenting empirical research and methodological reviews that examine the role genetics has in behavioral research. This special issue highlights the strengths, challenges, and methodological approaches that can be used to incorporate genetic and other biological data (e.g., epigenetic markers) into prevention science. The papers in this special issue cover several overarching themes that have emerged as critical for adequately incorporating genetics into prevention and other behavioral research, including gene-by-intervention (Gxl) studies. The collection of papers reflect examples, suggestions, opportunities, and pitfalls (and how to avoid them) when incorporating genetics or other biological data into prevention research. Below, we highlight some of the themes and strengths of Gxl research as reflected in the set of studies included in this special issue.
随着高通量技术的最新进展,遗传和其他生物数据越来越多地被纳入社会科学研究,包括预防/干预研究。了解遗传学在预防/干预研究中经常评估的复杂行为中所起的作用,对于设计预防方案、确定谁接受某些预防方案以及理解方案效果的个体差异(见 Jaffee & Price, 2007; Moffitt, Caspi, & Rutter, 2006)具有重要意义。本期特刊旨在通过展示实证研究和方法学评论,推进这一领域的工作,这些研究和评论探讨了遗传学在行为研究中的作用。本期特刊突出了将遗传和其他生物数据(如表观遗传标记)纳入预防科学的优势、挑战和方法途径。本期特刊中的论文涵盖了几个作为将遗传学充分纳入预防和其他行为研究的关键的总体主题,包括基因与干预(Gxl)研究。这组论文反映了将遗传学或其他生物数据纳入预防研究中的实例、建议、机会和陷阱(以及如何避免这些陷阱)。下面,我们将重点介绍 Gxl 研究的一些主题和优势,这些主题和优势反映在本期特刊中包含的一系列研究中。