Bársony J, Lakatos P, Földes J, Fehér T
Acta Endocrinol (Copenh). 1986 Nov;113(3):329-34.
Twelve hypothyroid subjects, 13 healthy and 12 healthy women with a slight deficiency of vitamin D were studied to distinguish seasonal changes from the thyroxine-dependent ones. Serum 25-hydroxyvitamin D levels of hypothyroid patients were lower than those of healthy individuals when the sera were obtained in the autumn. In hypothyroid patients a single oral dose of 100,000 IU vitamin D3 resulted in a smaller increase in 25-hydroxyvitamin D concentration than in controls having subclinical exogenous vitamin D deficiency. Substitution therapy with thyroid hormone, started in our study always in autumn, increased the 25-hydroxyvitamin D concentration in hypothyroid patients, which was opposite to the autumn-to-spring variation of this hormone observed in healthy controls. The increase of 25-hydroxyvitamin D, dehydroepiandrosterone and its sulphate values following substitution therapy in the hypothyroid patients may indicate that thyroid hormone(s) is (are) involved in the regulation of steroid hormone synthesis.
对12名甲状腺功能减退患者、13名健康人以及12名维生素D略有缺乏的健康女性进行了研究，以区分季节性变化与甲状腺素依赖性变化。秋季采集血清时，甲状腺功能减退患者的血清25-羟维生素D水平低于健康个体。与存在亚临床外源性维生素D缺乏的对照组相比，甲状腺功能减退患者单次口服100,000 IU维生素D3后，25-羟维生素D浓度的升高幅度较小。在我们的研究中，甲状腺激素替代治疗总是在秋季开始，这使甲状腺功能减退患者的25-羟维生素D浓度升高，这与健康对照组中该激素从秋季到春季的变化相反。甲状腺功能减退患者在替代治疗后25-羟维生素D、脱氢表雄酮及其硫酸盐值的升高可能表明甲状腺激素参与了类固醇激素合成的调节。
