在小鼠模型中对过敏原特异性免疫治疗佐剂的比较研究。
Comparative study of adjuvants for allergen-specific immunotherapy in a murine model.
机构信息
Allergy Service, Infanta Leonor University Hospital, Madrid, Spain.
Allergy Service, Gregorio Marañón University General Hospital, Madrid, Spain.
出版信息
Immunotherapy. 2018 Oct;10(14):1219-1228. doi: 10.2217/imt-2018-0072. Epub 2018 Sep 24.
AIM
To compare the immunological and clinical changes induced by allergen-specific immunotherapy (AIT) using different adjuvants.
MATERIALS & METHODS: Olea europaea pollen-sensitized mice were treated with olea plus aluminum hydroxide, calcium phosphate, monophosphoryl lipid A (MPL) or immunostimulatory sequences (ISS).
RESULTS
Aluminum hydroxide seems to drive initially to a Th2-type response. Bacteria-derived adjuvants (MPL and ISS) skew the immune response toward Th1 and Treg pathways. Specific-IgE production was lower after AIT with MPL and ISS. Moreover, IgG2a production significantly increased in ISS-treated mice. Bacteria-derived adjuvants also improved the Th1 cytokine response due to IFN-γ higher secretion. In addition, they improved bronchial hyper-reactivity and lung inflammation.
CONCLUSION
Bacteria-derived adjuvants may enhance the efficacy of AIT.
目的
比较不同佐剂诱导的变应原特异性免疫治疗（AIT）的免疫和临床变化。
材料与方法
用橄榄花粉致敏的小鼠用橄榄油加氢氧化铝、磷酸钙、单磷酰脂质 A（MPL）或免疫刺激序列（ISS）进行治疗。
结果
氢氧化铝似乎最初导致 Th2 型反应。细菌来源的佐剂（MPL 和 ISS）使免疫反应偏向 Th1 和 Treg 途径。用 MPL 和 ISS 进行 AIT 后，特异性 IgE 产生减少。此外，ISS 治疗的小鼠 IgG2a 产生显著增加。由于 IFN-γ的分泌增加，细菌来源的佐剂也改善了 Th1 细胞因子反应。此外，它们改善了支气管高反应性和肺部炎症。
结论
细菌来源的佐剂可能增强 AIT 的疗效。
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