Department of Psychiatry, Indiana University School of Medicine, Indiana University Health Neuroscience Center, Indianapolis, Indiana; Sandra Eskenazi Center for Brain Care Innovation, Eskenazi Hospital, Indianapolis, Indiana.
Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Internal Medicine, Indiana University School of Medicine, Indianapolis, Indiana.
Ann Thorac Surg. 2018 Oct;106(4):966-972. doi: 10.1016/j.athoracsur.2018.05.089. Epub 2018 Jul 3.
Obstructive sleep apnea (OSA) is associated with higher rates of postoperative delirium. The relationship between preoperative OSA risk and postoperative delirium and coma in thoracic surgery patients hospitalized in the intensive care unit (ICU) is not well understood. This study tests the hypothesis that thoracic surgery patients hospitalized in ICU with a higher preoperative risk for OSA are more likely to develop postoperative delirium and coma, resulting in longer hospital stays.
Preoperative OSA risk was measured using the STOP-BANG questionnaire. STOP-BANG scores of greater than or equal to 3 were defined as intermediate-high risk for OSA; 128 patients who underwent major thoracic surgery completed the STOP-BANG questionnaire preoperatively. The Richmond Agitation and Sedation Scale was used to assess level of consciousness. The Confusion Assessment Method for the ICU was used to assess for delirium. Linear regression was used to assess the relationship between risk of OSA and outcome measures. Results were adjusted for age, sex, body mass index, Charlson Comorbidity Index, instrumental activities of daily living, and surgery type.
A total of 96 of 128 patients (76%) were in the intermediate-high-risk OSA group. Adjusted analyses showed that the intermediate-high-risk OSA group had a longer duration of postoperative ICU delirium and coma compared with the low-risk OSA group (1.4 ± 1.3 days versus 0.9 ± 1.4 days; P = 0.04). Total number of hospital days was not significantly different.
Higher preoperative risk for OSA in thoracic surgery patients was associated with a longer duration of postoperative delirium and coma.
阻塞性睡眠呼吸暂停(OSA)与术后谵妄发生率较高有关。术前 OSA 风险与 ICU 住院的胸外科患者术后谵妄和昏迷之间的关系尚未得到很好的理解。本研究检验了以下假设:在 ICU 住院的胸外科患者,术前 OSA 风险较高,更有可能发生术后谵妄和昏迷,导致住院时间延长。
使用 STOP-BANG 问卷测量术前 OSA 风险。STOP-BANG 评分大于等于 3 定义为 OSA 中高危;128 例接受大胸手术的患者术前完成 STOP-BANG 问卷。使用 Richmond 躁动镇静量表评估意识水平。使用 ICU 意识混乱评估方法评估谵妄。线性回归用于评估 OSA 风险与结局测量之间的关系。结果根据年龄、性别、体重指数、Charlson 合并症指数、工具性日常生活活动和手术类型进行调整。
128 例患者中有 96 例(76%)为中高危 OSA 组。调整分析显示,中高危 OSA 组术后 ICU 谵妄和昏迷时间长于低危 OSA 组(1.4 ± 1.3 天与 0.9 ± 1.4 天;P=0.04)。总住院天数无显著差异。
胸外科患者术前 OSA 风险较高与术后谵妄和昏迷时间延长有关。