介孔二氧化硅纳米材料及其生物医学应用的研究综述

Overview of Studies Regarding Mesoporous Silica Nanomaterials and Their Biomedical Application.

作者信息

Vallet-Regi Maria, Tamanoi Fuyuhiko

机构信息

Department of Chemistry in Pharmaceutical Sciences, School of Pharmacy, Universidad Complutense de Madrid and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.

Integrated Institute for Cell-Materials Science, Institute for Advanced Study, Kyoto University, Kyoto, Japan; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, United States.

出版信息

Enzymes. 2018;43:1-10. doi: 10.1016/bs.enz.2018.07.001. Epub 2018 Sep 10.

DOI:10.1016/bs.enz.2018.07.001

PMID:30244802

Abstract

Synthesis of mesoporous silica nanomaterials occurred in the late 1980s and early 1990s. Since then, we have seen dramatic increase in the number of publication dealing with this nanomaterial. In particular, there have been a large number of publications regarding biomedical application of mesoporous silica nanoparticles including their use in cancer therapy and diagnosis. Various surface modification strategies have been explored to enhance drug loading and to target them to tumor. In addition, the nanoparticles have been armed with controlled release capability. In this review, we point out some crucial issues regarding the material, which will be discussed in more detail in chapters of this volume.

摘要

介孔二氧化硅纳米材料的合成始于20世纪80年代末和90年代初。从那时起，我们看到关于这种纳米材料的出版物数量急剧增加。特别是，有大量关于介孔二氧化硅纳米颗粒生物医学应用的出版物，包括它们在癌症治疗和诊断中的应用。人们探索了各种表面改性策略来提高药物负载量并使其靶向肿瘤。此外，这些纳米颗粒还具备控释能力。在这篇综述中，我们指出了有关该材料的一些关键问题，这些问题将在本卷各章中更详细地讨论。