Mitrovic D
Ann Biol Clin (Paris). 1986;44(3):281-4.
The articular cartilage is frequently destroyed in rheumatic diseases. Among the various responsible factors, enzymes and especially collagenases play a leading role. Their action explains the collagen degradation linked with cartilage destruction. The author recalls the origin, mechanism of action of the articular collagenases and discusses their role in the articular cartilage degradation in rheumatic diseases.
关节软骨在风湿性疾病中常遭破坏。在各种相关因素中,酶尤其是胶原酶起主要作用。它们的作用解释了与软骨破坏相关的胶原蛋白降解。作者回顾了关节胶原酶的起源、作用机制,并讨论了它们在风湿性疾病关节软骨降解中的作用。