State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China.
Biomedical Barriers Research Center, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Biomedical Materials, Tianjin, 300192, China.
Chem Commun (Camb). 2018 Oct 14;54(80):11356-11359. doi: 10.1039/c8cc04958k. Epub 2018 Sep 24.
Magnetic poly(l-lactide) coarse microspheres were synthesized via an emulsion method followed by chemical etching. Subsequently, anti-CD3 and anti-CD28 antibodies were attached to the microspheres via an avidin-biotin amplification system as artificial antigen-presenting cells. The activation of T cells was enhanced significantly due to the surface topographic structure and increased signal molecule amount.
磁性聚（L-丙交酯）粗微球通过乳液法合成，然后进行化学蚀刻。随后，通过亲和素-生物素放大系统将抗 CD3 和抗 CD28 抗体连接到微球上，作为人工抗原呈递细胞。由于表面形貌结构和信号分子数量的增加，T 细胞的激活得到了显著增强。
