Miao Ailiang, Du Mingyang, Wang Lingling, Ge Jianqing, Lu Hengdong, Xu Haiyan, Liu Hongxing, Yu Chuanyong, Wu Caiyun, Gao Yuan, Sun Jintao, Shi Qi, Wang Xiaoshan
1 Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
2 Department of Video-Electroencephalogram, Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Clin EEG Neurosci. 2019 Jan;50(1):56-62. doi: 10.1177/1550059418800867. Epub 2018 Sep 24.
This study aimed to determine the relation between electroclinical features and cerebrospinal fluid (CSF) antibody titers in patients with anti- N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis.
Clinical symptoms and electroencephalography (EEG) at different stages were analyzed in 51 hospitalized patients with anti-NMDAR encephalitis.
Behavioral changes were the initial symptoms in 90.9% (20/22) of female patients with high (1:10 or 1:32) CSF antibody titers. A greater number of clinical symptoms were observed in the patients with high CSF antibody titers than in those with low (1:1 or 1:3.2) CSF antibody titers (mean 3.11 ± 1.06 vs 1.62 ± 0.65, P = .000). The number of clinical symptoms was greater in the female patients than in the male patients (mean 3.52 ± 0.98 vs 2.69 ± 1.09, P = .000). At the peak stage, worse background activity (BA) in EEG recordings was observed in patients with high CSF antibody titers than in those with low CSF antibody titers (Mann-Whitney U test, P = .001). The peak-stage BA in EEG was worse in female patients than in male patients (Mann-Whitney U test, P = .000). Modified Rankin scale scores were higher in patients with high CSF antibody titers than in those with low CSF antibody titers (mean 2.62 ± 1.42 vs 0.75 ± 0.97, P = .000). Brush patterns and constant chewing were observed primarily in female patients with high CSF antibody titers. Epileptic discharges were located predominately in the frontal regions and were noted to vary.
The electroclinical features of patients with anti-NMDAR encephalitis were associated with gender and CSF antibody titers.
本研究旨在确定抗N-甲基-D-天冬氨酸受体（抗NMDAR）脑炎患者的电临床特征与脑脊液（CSF）抗体滴度之间的关系。
对51例住院的抗NMDAR脑炎患者不同阶段的临床症状和脑电图（EEG）进行分析。
脑脊液抗体滴度高（1:10或1:32）的女性患者中，行为改变是90.9%（20/22）的初始症状。脑脊液抗体滴度高的患者比滴度低（1:1或1:3.2）的患者出现更多的临床症状（平均3.11±1.06对1.62±0.65，P = 0.000）。女性患者的临床症状数量多于男性患者（平均3.52±0.98对2.69±1.09，P = 0.
