Miao Ailiang, Shi Yongwei, Xiang Jing, Wang Xiaoshan, Ge Jianqing, Chen Qiqi, Yu Yuanwen, Yu Chuanyong, Wu Di
Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, Guang Zhou Road 264, Jiangsu, 210029, Nanjing, China.
Department of Video-Electroencephalogram, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, Jiangsu, Nanjing, China.
BMC Neurol. 2021 Mar 22;21(1):134. doi: 10.1186/s12883-021-02157-0.
Extreme delta brush (EDB) is considered a potential marker for anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. The brain regions involved in EDB are unclear.
A 16-year-old woman with anti-NMDAR encephalitis who was experiencing psychosis was admitted. Electroencephalography (EEG) and magnetoencephalography (MEG) were used to analyze EDB in the patient. EDB on EEG could be disturbed by opening and closing the eyes, by occipital alpha rhythms and by sleep-wake cycles. The MEG results showed beta activity originating from bilateral superior parietal lobes. However, the delta wave originated from bilateral superior temporal gyri, the right middle temporal gyrus, the right inferior frontal gyrus, and the left inferior parietal lobe.
Delta wave and beta activity might originate from different brain regions. Beta activity might be transmitted forward to the frontotemporal lobe and superimposed with delta activity to form EDB on EEG.
极慢波（EDB）被认为是抗N-甲基-D-天冬氨酸受体（抗NMDAR）脑炎的潜在标志物。EDB所涉及的脑区尚不清楚。
一名患有抗NMDAR脑炎且出现精神病症状的16岁女性入院。采用脑电图（EEG）和脑磁图（MEG）分析该患者的EDB。EEG上的EDB可因睁眼和闭眼、枕部α节律以及睡眠-觉醒周期而受到干扰。MEG结果显示β活动起源于双侧顶上叶。然而，δ波起源于双侧颞上回、右侧颞中回、右侧额下回和左侧顶下小叶。
δ波和β活动可能起源于不同的脑区。β活动可能向前传导至额颞叶，并与δ活动叠加，在EEG上形成EDB。
