运动对轻度认知障碍患者记忆功能的实验性影响：系统评价与荟萃分析。

Experimental effects of exercise on memory function among mild cognitive impairment: systematic review and meta-analysis.

作者信息

Loprinzi Paul D, Blough Jeremiah, Ryu Seungho, Kang Minsoo

机构信息

a Exercise & Memory Laboratory, Department of Health, Exercise Science, and Recreation Management , University of Mississippi , Oxford , USA.

b Health and Sport Analytics Laboratory, Department of Health, Exercise Science, and Recreation Management , University of Mississippi , Oxford , USA.

出版信息

Phys Sportsmed. 2019 Feb;47(1):21-26. doi: 10.1080/00913847.2018.1527647. Epub 2018 Oct 8.

DOI:10.1080/00913847.2018.1527647

PMID:30246596

Abstract

OBJECTIVE

The objective of this study was to evaluate the experimental effects of exercise on memory function among adults with mild cognitive impairment (MCI).

METHODS

A systematic review and meta-analysis were employed. Studies were identified using electronic databases, including PubMed, PsychInfo, SPORTDiscus, and Google Scholar. To be eligible for inclusion, studies had to employ an experimental design, be conducted in humans (no animal models) with mild cognitive impairment, include an exercise intervention arm (either acute exercise or chronic training), and measure memory function (any type) as the outcome measure. Comprehensive Meta-Analysis software was used to compute the standardized mean difference effect size (Cohen's d) and 95% CI using a random-effects model.

RESULTS

In total, 11 studies met our criteria, contributing to 20 effect size estimates. Among the 20 effect size estimates, 13 contributed to a short-term memory recall, with 7 contributing to a delayed/long-term memory recall. The overall weighted mean effect size was d = 0.30 (95% CI: 0.16-0.44; P < 0.001), indicating a small to medium effect of exercise on improving memory function. For the moderation analysis, there was no evidence of a moderation effect for recall duration (Q = 0.004, df(1), P = 0.95), as exercise (vs. control) demonstrated both short-term (d = 0.31; 95% CI: 0.14-0.47; P < 0.001) and long-term memory (d = 0.29; 95% CI: 0.06-0.53; P = 0.013) benefits.

CONCLUSION

Current evidence suggests that exercise may help to improve memory function among those with MCI. Safe and progressive forms of exercise should be promoted among MCI patients.

摘要

目的

本研究的目的是评估运动对轻度认知障碍（MCI）成年人记忆功能的实验效果。

方法

采用系统评价和荟萃分析。通过电子数据库识别研究，包括PubMed、PsychInfo、SPORTDiscus和谷歌学术。要符合纳入标准，研究必须采用实验设计，在患有轻度认知障碍的人类（无动物模型）中进行，包括运动干预组（急性运动或长期训练），并将记忆功能（任何类型）作为结局指标进行测量。使用综合荟萃分析软件，采用随机效应模型计算标准化平均差效应量（科恩d值）和95%置信区间。

结果

共有11项研究符合我们的标准，得出20个效应量估计值。在这20个效应量估计值中，13个有助于短期记忆回忆，7个有助于延迟/长期记忆回忆。总体加权平均效应量为d = 0.30（95%置信区间：0.16 - 0.44；P < 0.001），表明运动对改善记忆功能有小到中等的效果。对于调节分析，没有证据表明回忆持续时间有调节效应（Q = 0.004，自由度(1)，P = 0.95），因为运动（与对照组相比）显示出短期（d = 0.31；95%置信区间：0.14 - 0.47；P < 0.001）和长期记忆（d = 0.29；95%置信区间：0.06 - 0.53；P = 0.013）的益处。