联合认知和身体锻炼训练对轻度认知障碍或痴呆老年人认知功能的积极影响：荟萃分析。
Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: A meta-analysis.
机构信息
Department of Geriatric Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands; Radboudumc Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Medical Psychology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
出版信息
Ageing Res Rev. 2017 Nov;40:75-83. doi: 10.1016/j.arr.2017.09.003. Epub 2017 Sep 12.
Combined cognitive and physical exercise interventions have potential to elicit cognitive benefits in older adults with mild cognitive impairment (MCI) or dementia. This meta-analysis aims to quantify the overall effect of these interventions on global cognitive functioning in older adults with MCI or dementia. Ten randomized controlled trials that applied a combined cognitive-physical intervention with cognitive function as an outcome measure were included. For each study effect sizes were computed (i.e., post-intervention standardized mean difference (SMD) scores) and pooled, using a random-effects meta-analysis. The primary analysis showed a small-to-medium positive effect of combined cognitive-physical interventions on global cognitive function in older adults with MCI or dementia (SMD[95% confidence interval]=0.32[0.17;0.47], p<0.00). A combined intervention was equally beneficial in patients with dementia (SMD=0.36[0.12;0.60], p<0.00) and MCI (SMD=0.39[0.15;0.63], p<0.05). In addition, the analysis showed a moderate-to-large positive effect after combined cognitive-physical interventions for activities of daily living (ADL) (SMD=0.65[0.09;1.21], p<0.01)and a small-to-medium positive effect for mood (SMD=0.27[0.04;0.50], p<0.01). These functional benefits emphasize the clinical relevance of combined cognitive and physical training strategies.
联合认知和身体锻炼干预措施有可能为轻度认知障碍（MCI）或痴呆症的老年人带来认知益处。本荟萃分析旨在量化这些干预措施对 MCI 或痴呆症老年患者整体认知功能的总体影响。纳入了 10 项应用联合认知-身体干预措施并以认知功能为结果测量的随机对照试验。对每项研究均计算了效应大小（即干预后的标准化均数差值（SMD）评分），并使用随机效应荟萃分析进行汇总。主要分析显示，联合认知-身体干预措施对 MCI 或痴呆症老年患者的整体认知功能具有较小到中等的积极影响（SMD[95%置信区间]=0.32[0.17;0.47]，p<0.00）。联合干预对痴呆症患者（SMD=0.36[0.12;0.60]，p<0.00）和 MCI 患者（SMD=0.39[0.15;0.63]，p<0.05）同样有益。此外，分析还显示，联合认知-身体干预措施对日常生活活动（ADL）有中度到较大的积极影响（SMD=0.65[0.09;1.21]，p<0.01），对情绪有较小到中等的积极影响（SMD=0.27[0.04;0.50]，p<0.01）。这些功能益处强调了联合认知和身体训练策略的临床相关性。
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