Zampino Rosa, Macera Margherita, Cirillo Grazia, Pafundi Pia Clara, Rinaldi Luca, Coppola Nicola, Pisaturo Mariantonietta, Adinolfi Luigi Elio, Miraglia Del Giudice Emanuele, Ingrosso Diego, Capasso Rosanna
Department of Medical, Surgical, Neurological, Metabolic and Aging Science, University of Campania "Luigi Vanvitelli", Italy.
Department of Public Medicine, Section of Infectious Diseases, University of Campania "Luigi Vanvitelli", Italy.
Infez Med. 2018 Sep 1;26(3):244-248.
PNPLA3 and MTP genes have been associated with liver steatosis and chronic hepatitis C. We studied the influence of MTP and PNPLA3 polymorphisms in 114 Italian patients with chronic hepatitis C, evaluating the histological and clinical presentation of liver disease. The study confirmed the association of PNPLA3 polymorphisms with liver steatosis (p=0.041), but did not show any additive effect of MTP polymorphisms in the development of steatosis. MTP polymorphisms do not seem to influence PNPLA3 in the development of liver steatosis. Further studies with a larger number of patients are required.
