Cerda J, Urizar R E, Conran R, Blumenstock F A, Kaplan J E, Malik A B, Simon R
Br J Exp Pathol. 1986 Oct;67(5):623-8.
Levels of plasma fibronectin (Fn) were 63% lower than normal 15 min after the intravenous injection of liquoid (P less than 0.01); 3 h later they were still low but rebounded to 35% above normal (P less than 0.01) by 24 h. Concurrently microthrombi containing fibrinogen, Fn and Factor VIII related-antigens (VIII:Ag) were detected in the kidneys and lungs by immunohistopathological studies. Ultrastructurally, thrombi were composed of dense granular and occasional fibrillar non-striated material. In liquoid-injected rats 125I-fibrinogen mainly localized in kidneys and lungs, especially in the latter (P less than 0.01), and the lungs had a higher wet-to-dry weight ratios than did controls (P less than 0.01). It is concluded that the polyanion (liquoid)-induced intravascular coagulation-like reaction sequestered Fn concomitantly with the precipitation of fibrinogen and VII:Ag in the microclots. The reduced concentration of plasma Fn may have impaired the disposal of coagulation products thus enhancing the expression of the coagulopathy-mediated renal and pulmonary histopathology. It is suggested that the liquoid-related coagulopathy may have resulted in enzymatic lysis of Fn.
静脉注射磺溴酞钠后15分钟，血浆纤连蛋白（Fn）水平比正常水平低63%（P<0.01）；3小时后其水平仍较低，但到24小时时回升至比正常水平高35%（P<0.01）。同时，通过免疫组织病理学研究在肾脏和肺中检测到含有纤维蛋白原、Fn和因子VIII相关抗原（VIII:Ag）的微血栓。在超微结构上，血栓由致密颗粒和偶尔的纤维状无横纹物质组成。在注射磺溴酞钠的大鼠中，125I-纤维蛋白原主要定位于肾脏和肺，尤其是后者（P<0.01），并且肺的湿重与干重之比高于对照组（P<0.01）。得出的结论是，聚阴离子（磺溴酞钠）诱导的血管内凝血样反应在微血栓中使Fn与纤维蛋白原和VII:Ag的沉淀同时被隔离。血浆Fn浓度降低可能损害了凝血产物的清除，从而增强了凝血病介导的肾脏和肺部组织病理学表现。提示磺溴酞钠相关的凝血病可能导致了Fn的酶解。
