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中肠来源的神经肽 F 以交配依赖的方式控制生殖干细胞的增殖。

Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner.

机构信息

Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, United States of America.

出版信息

PLoS Biol. 2018 Sep 24;16(9):e2005004. doi: 10.1371/journal.pbio.2005004. eCollection 2018 Sep.

DOI:10.1371/journal.pbio.2005004
PMID:30248087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6152996/
Abstract

Stem cell maintenance is established by neighboring niche cells that promote stem cell self-renewal. However, it is poorly understood how stem cell activity is regulated by systemic, tissue-extrinsic signals in response to environmental cues and changes in physiological status. Here, we show that neuropeptide F (NPF) signaling plays an important role in the pathway regulating mating-induced germline stem cell (GSC) proliferation in the fruit fly Drosophila melanogaster. NPF expressed in enteroendocrine cells (EECs) of the midgut is released in response to the seminal-fluid protein sex peptide (SP) upon mating. This midgut-derived NPF controls mating-induced GSC proliferation via ovarian NPF receptor (NPFR) activity, which modulates bone morphogenetic protein (BMP) signaling levels in GSCs. Our study provides a molecular mechanism that describes how a gut-derived systemic factor couples stem cell behavior to physiological status, such as mating, through interorgan communication.

摘要

干细胞的维持是由邻近的生态位细胞建立的，这些细胞促进干细胞自我更新。然而，人们对于干细胞活性如何受到系统性、组织外信号的调节，以响应环境线索和生理状态的变化，知之甚少。在这里，我们表明神经肽 F (NPF) 信号在调节果蝇生殖干细胞 (GSC) 增殖的途径中起着重要作用。中肠内分泌细胞 (EEC) 表达的 NPF 在交配时响应精液蛋白性肽 (SP) 释放。这种来源于肠道的 NPF 通过卵巢 NPF 受体 (NPFR) 的活性来控制交配诱导的 GSC 增殖，从而调节 GSCs 中的骨形态发生蛋白 (BMP) 信号水平。我们的研究提供了一个分子机制，描述了一种肠道衍生的系统因素如何通过器官间通讯将干细胞行为与生理状态（如交配）联系起来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/a00dd99c963f/pbio.2005004.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/00792fdbde5c/pbio.2005004.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/3b75342ba8bb/pbio.2005004.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/44539ac738a0/pbio.2005004.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/465bc3d8842b/pbio.2005004.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/a1035c16dec1/pbio.2005004.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/e4e0b1b89445/pbio.2005004.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/a00dd99c963f/pbio.2005004.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/00792fdbde5c/pbio.2005004.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/3b75342ba8bb/pbio.2005004.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/44539ac738a0/pbio.2005004.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/465bc3d8842b/pbio.2005004.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/a1035c16dec1/pbio.2005004.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/e4e0b1b89445/pbio.2005004.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c70/6152996/a00dd99c963f/pbio.2005004.g007.jpg

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