类固醇激素与组织驻留干细胞的生理调节：来自卵巢的经验教训。
Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Ovary.
作者信息
Ables Elizabeth T, Drummond-Barbosa Daniela
机构信息
Department of Biology, East Carolina University, Greenville, NC 27858, USA.
Department of Biochemistry and Molecular Biology, Division of Reproductive Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
出版信息
Curr Stem Cell Rep. 2017 Mar;3(1):9-18. doi: 10.1007/s40778-017-0070-z. Epub 2017 Feb 1.
PURPOSE OF REVIEW
Stem cells respond to local paracrine signals; more recently, however, systemic hormones have also emerged as key regulators of stem cells. This review explores the role of steroid hormones in stem cells, using the germline stem cell as a centerpiece for discussion.
RECENT FINDINGS
Stem cells sense and respond directly and indirectly to steroid hormones, which regulate diverse sets of target genes via interactions with nuclear hormone receptors. Hormone-regulated networks likely integrate the actions of multiple systemic signals to adjust the activity of stem cell lineages in response to changes in physiological status.
SUMMARY
Hormones are inextricably linked to animal physiology, and can control stem cells and their local niches. Elucidating the molecular mechanisms of hormone signaling in stem cells is essential for our understanding of the fundamental underpinnings of stem cell biology, and for informing new therapeutic interventions against cancers or for regenerative medicine.
综述目的
干细胞对局部旁分泌信号作出反应；然而，最近全身性激素也已成为干细胞的关键调节因子。本综述以生殖系干细胞为核心探讨类固醇激素在干细胞中的作用。
最新发现
干细胞直接和间接感知并响应类固醇激素，这些激素通过与核激素受体相互作用来调节多种靶基因。激素调节网络可能整合多种全身信号的作用，以响应生理状态变化来调节干细胞谱系的活性。
总结
激素与动物生理学紧密相连，能够控制干细胞及其局部微环境。阐明干细胞中激素信号传导的分子机制对于我们理解干细胞生物学的基本基础以及为癌症新治疗干预措施或再生医学提供依据至关重要。
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