Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China; Guangdong Provincial Key Laboratory of Clinical Pharmacology, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China.
Heart Rhythm. 2019 Mar;16(3):380-387. doi: 10.1016/j.hrthm.2018.09.015. Epub 2018 Sep 21.
Ablation of para-Hisian ventricular arrhythmias (PH-VAs) is challenging because of the close relationship of the origin site and His bundle. Using pacing techniques to differentiate the near-field from far-field His activations, thereby avoiding atrioventricular block, has been reported in patients with para-Hisian accessory pathways.
We applied the same pacing technique and 3-dimensional mapping to guide radiofrequency (RF) ablation in patients with right-sided PH-VAs and investigated the clinical outcome of such cases.
Fourteen patients with right-sided PH-VAs were included in this study. The earliest activation sites were confirmed in the right ventricle on the 3-dimensional map. Pacing with different outputs was performed at the largest His potential site (P1) and the earliest activation site (P2). If the minimum His bundle-right bundle branch-captured output at P2 was higher than that at P1, RF ablation was performed at the site.
All the patients in this study had monomorphic premature ventricular contractions (PVCs) with a mean QRS duration of 118.3 ± 8.1 ms. A His-right bundle branch potential with an amplitude of 0.05 ± 0.02 mV was recorded at P2, with a mean distance of 5.97 ± 1.84 mm away from P1. PVCs were successfully eliminated in 13 of 14 patients (92.9%). One patient exhibited persistent right bundle branch block after ablation, and 1 recurrence of ablated PVCs occurred during a median follow-up period of 15 months.
Using a simple pacing technique to evaluate the safety of RF energy application led to a high success rate of RF catheter ablation of right-sided PH-VAs without atrioventricular block.
由于起源部位与希氏束的密切关系,消融旁希氏区室性心律失常(PH-VAs)具有挑战性。已有研究报道,在存在旁希氏旁路的患者中,使用起搏技术来区分近场和远场希氏激活,从而避免房室传导阻滞。
我们应用相同的起搏技术和 3 维标测指导右侧 PH-VAs 的射频(RF)消融,并研究了此类病例的临床结果。
本研究纳入了 14 例右侧 PH-VAs 患者。在 3 维标测图上,首先确定右心室最早的激活部位。在最大希氏电位部位(P1)和最早激活部位(P2)进行不同输出的起搏。如果 P2 的最小希氏束-右束支夺获输出高于 P1,则在该部位行 RF 消融。
本研究所有患者均表现为形态单一的室性期前收缩(PVCs),平均 QRS 波时限为 118.3±8.1 ms。在 P2 记录到一个希氏-右束支电位,幅度为 0.05±0.02 mV,距离 P1 的平均距离为 5.97±1.84 mm。14 例患者中有 13 例(92.9%)PVCs 成功消除。1 例患者消融后持续存在右束支阻滞,1 例患者在中位随访 15 个月时出现消融 PVCs 复发。
应用一种简单的起搏技术评估 RF 能量应用的安全性,可使右侧 PH-VAs 的 RF 导管消融成功率高,且不伴房室传导阻滞。