Lin Cheng-Chieh, Tang Kuo-Tung, Li Chia-Ing, Liu Chiu-Shong, Lai Ming-May, Lin Wen-Yuan, Lin Cheng-Chieh
Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
Department of Family Medicine, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Kidney Blood Press Res. 2018;43(5):1479-1487. doi: 10.1159/000493663. Epub 2018 Sep 24.
BACKGROUND/AIMS: Brachial-ankle pulse wave velocity (baPWV) reflects the stiffness of muscular arteries. Albuminuria is recognized as a marker of vascular dysfunction. We assessed the association between arterial stiffness and albuminuria in a population-based longitudinal study.
1116 adults aged ≥ 40 years in the Taichung Community Health Study (TCHS) in 2004 attended a follow-up visit in 2011. Albuminuria was defined as an urinary albumin-to-creatinine ratio (UACR) ≥ 30 mg/g. Arterial stiffness was defined as BaPWV ≥ 1540 cm/sec in males and BaPWV ≥ 1480 cm/sec in females, respectively. ∆baPWV was calculated as baPWV at follow-up minus baPWV at baseline, while ∆UACR was calculated as UACR at follow-up minus UACR at baseline. Multiple linear and logistic regression analyses were used to explore the relationship between albuminuria and arterial stiffness.
Among 652 subjects without arterial stiffness at baseline, 209 (32%) subjects developed incident arterial stiffness after an average of 6.6 years. In male subjects, baseline albuminuria was associated with development of arterial stiffness (odds ratio: 4.47, 95% confidence interval [CI]: 1.04-19.31) and ∆baPWV was modestly positively associated with ∆UACR.
Our results indicated that male adults with albuminuria had an increased risk for developing arterial stiffness.
背景/目的：肱踝脉搏波速度（baPWV）反映肌性动脉的僵硬度。蛋白尿被认为是血管功能障碍的一个标志物。我们在一项基于人群的纵向研究中评估了动脉僵硬度与蛋白尿之间的关联。
2004年参加台中社区健康研究（TCHS）的1116名年龄≥40岁的成年人于2011年进行了随访。蛋白尿定义为尿白蛋白与肌酐比值（UACR）≥30mg/g。动脉僵硬度分别定义为男性BaPWV≥1540cm/秒，女性BaPWV≥1480cm/秒。∆baPWV计算为随访时的baPWV减去基线时的baPWV，而∆UACR计算为随访时的UACR减去基线时的UACR。采用多元线性和逻辑回归分析来探讨蛋白尿与动脉僵硬度之间的关系。
在652名基线时无动脉僵硬度的受试者中，209名（32%）受试者在平均6.6年后出现新发动脉僵硬度。在男性受试者中，基线蛋白尿与动脉僵硬度的发生相关（比值比：4.47，95%置信区间[CI]：1.04 - 19.31），且∆baPWV与∆UACR呈适度正相关。
我们的结果表明，有蛋白尿的男性成年人发生动脉僵硬度的风险增加。
