Evans P J, Dieguez C, Rees L H, Hall R, Scanlon M F
Clin Endocrinol (Oxf). 1986 Jun;24(6):687-91. doi: 10.1111/j.1365-2265.1986.tb01665.x.
To assess the effect of cholinergic blockade on the ACTH, beta-endorphin and cortisol responses to insulin-induced hypoglycaemia, six healthy male volunteers each underwent two insulin tolerance tests in random order, separated by at least 1 week with and without atropine. ACTH levels were significantly greater at +45 min (mean +/- SEM, 223 +/- 21 pg/ml vs 148 +/- 15 pg/ml, P less than 0.01) and at +120 min (54 +/- 11 pg/ml vs 29 +/- 10 pg/ml, P less than 0.05). beta-endorphin levels were significantly greater at +30 min (170 +/- 45 pg/ml vs 96 +/- 32 pg/ml, P less than 0.05) and at +105 min (81 +/- 14 pg/ml vs 54 +/- 7 pg/ml, P less than 0.01). Cholinergic blockade had no effect on plasma glucose or cortisol concentrations. This study demonstrates that cholinergic blockade with atropine facilitates the ACTH and beta-endorphin responses to insulin-induced hypoglycaemia without altering the cortisol responses.
为评估胆碱能阻断对促肾上腺皮质激素（ACTH）、β-内啡肽及皮质醇对胰岛素诱导低血糖反应的影响，六名健康男性志愿者每人按随机顺序接受两次胰岛素耐量试验，两次试验间隔至少1周，一次使用阿托品，一次不使用。在45分钟时促肾上腺皮质激素水平显著升高（均值±标准误，223±21 pg/ml对148±15 pg/ml，P<0.01），在120分钟时也显著升高（54±11 pg/ml对29±10 pg/ml，P<0.05）。β-内啡肽水平在30分钟时显著升高（170±45 pg/ml对96±32 pg/ml，P<0.05），在105分钟时也显著升高（81±14 pg/ml对54±7 pg/ml，P<0.01）。胆碱能阻断对血糖或皮质醇浓度无影响。本研究表明，阿托品进行胆碱能阻断可促进促肾上腺皮质激素和β-内啡肽对胰岛素诱导低血糖的反应，而不改变皮质醇反应。
