Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Biomedical Global Institute of Healthcare Research & Technology (BIGHEART), National University of Singapore, Singapore 119228, Singapore.
Int J Environ Res Public Health. 2018 Sep 21;15(10):2073. doi: 10.3390/ijerph15102073.
The aim of this study was to identify factors associated with high Framingham Risk Score (FRS) in medicated patients with major depressive disorder (MDD). We examined 61 medicated patients with MDD (mean age 37.77 ± 7.67, 90.2% women) and 43 non-depressed controls (mean age 38.26 ± 9.20, 90.7% women). We administered the Hamilton Depression Rating Scale (HAM-D) and measured systolic blood pressure (SBP), diastolic BP (DBP), mean arterial BP (MAP), pulse wave velocity (PWV), intima-media thickness (IMT), interleukin-6 (IL-6) and triglycerides. We found that medicated patients with MDD had significantly higher levels of HAM-D score ( < 0.01), SBP ( = 0.015), MAP ( = 0.037), IL-6 level ( = 0.007), as compared with controls. Medicated patients who remained moderately to severely depressed showed significantly higher SBP ( = 0.049), DBP ( = 0.009), MAP ( = 0.024), IL-6 level ( = 0.019), left PWV ( = 0.004) and average PWV ( = 0.026) than those with mild depression. Multivariate regression showed that the interaction effect between HAM-D score and triglyceride level ( = 0.018) was significantly associated with FRS in medicated patients with MDD. This study highlights that the interaction effect of the severity of depression and the triglyceride level, was a modifiable factor positively associated with high FRS.
本研究旨在确定与接受药物治疗的重度抑郁症(MDD)患者的弗雷明汉风险评分(FRS)升高相关的因素。我们共纳入 61 名接受药物治疗的 MDD 患者(平均年龄 37.77 ± 7.67 岁,90.2%为女性)和 43 名非抑郁对照者(平均年龄 38.26 ± 9.20 岁,90.7%为女性)。我们使用汉密尔顿抑郁量表(HAM-D)评估患者的抑郁严重程度,并测量收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、脉搏波速度(PWV)、内膜中层厚度(IMT)、白细胞介素-6(IL-6)和甘油三酯。结果显示,与对照组相比,接受药物治疗的 MDD 患者的 HAM-D 评分( < 0.01)、SBP( = 0.015)、MAP( = 0.037)和 IL-6 水平( = 0.007)均显著升高。与轻度抑郁患者相比,中重度抑郁患者的 SBP( = 0.049)、DBP( = 0.009)、MAP( = 0.024)、IL-6 水平( = 0.019)、左 PWV( = 0.004)和平均 PWV( = 0.026)也显著升高。多变量回归显示,HAM-D 评分和甘油三酯水平之间的交互效应( = 0.018)与 MDD 患者的 FRS 显著相关。综上,本研究提示抑郁严重程度与甘油三酯水平之间的交互效应是与 FRS 升高相关的可改变因素。