Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Obes Rev. 2017 Jul;18(7):742-754. doi: 10.1111/obr.12535. Epub 2017 Apr 12.
This meta-analysis aimed to evaluate the association between childhood and adolescent obesity and depression. We systematically searched PubMed, PsycInfo, EMBASE and Science Direct for studies that compared prevalence of depression and depressive symptoms in normal weight and obese children and adolescents. Observational studies were included if they reported body mass index and assessed depression by validated instruments or diagnostic interviews. Quality assessment was performed using the Newcastle-Ottawa scale. We used the random-effect model to calculate the pooled odds ratios, standard mean differences (SMDs) and subgroup analysis. Findings for a total of 51,272 participants were pooled across 18 studies and examined. Our analyses demonstrated a positive association between childhood and adolescent obesity and depression (pooled odds ratio = 1.34, 95% confidence interval [CI]: 1.1-1.64, p = 0.005) and more severe depressive symptoms (SMD = 0.23, 95% CI: 0.025-0.44, p = 0.028) in the obese groups. Overweight subjects were not more likely to have either depression (pooled odds ratio = 1.16, 95% CI: 0.93-1.44, p = 0.19) or depressive symptoms (SMD = 0, 95% CI: -0.101 to 0.102, p = 0.997). Non-Western and female obese subjects were significantly more likely to have depression and severe depressive symptoms (p < 0.05). In conclusion, obese children and adolescents are more likely to suffer from depression and depressive symptoms, with women and non-Western people at higher risk.
本荟萃分析旨在评估儿童和青少年肥胖与抑郁之间的关联。我们系统地检索了 PubMed、PsycInfo、EMBASE 和 Science Direct，以查找比较正常体重和肥胖儿童和青少年中抑郁和抑郁症状发生率的研究。如果研究报告了体重指数，并使用经过验证的工具或诊断性访谈评估了抑郁，则纳入观察性研究。使用纽卡斯尔-渥太华量表进行质量评估。我们使用随机效应模型计算汇总优势比、标准均数差 (SMD) 和亚组分析。对总共 51272 名参与者的研究结果进行了荟萃分析，共纳入了 18 项研究。我们的分析表明，儿童和青少年肥胖与抑郁之间存在正相关（汇总优势比=1.34，95%置信区间 [CI]：1.1-1.64，p=0.005），并且肥胖组的抑郁症状更为严重（SMD=0.23，95%CI：0.025-0.44，p=0.028）。超重者不太可能患有抑郁（汇总优势比=1.16，95%CI：0.93-1.44，p=0.19）或抑郁症状（SMD=0，95%CI：-0.101 至 0.102，p=0.997）。非西方和女性肥胖者更有可能患有抑郁和严重抑郁症状（p<0.05）。总之，肥胖的儿童和青少年更有可能患上抑郁和抑郁症状，女性和非西方人群的风险更高。
