Center for General Education, Taipei Medical University, Taipei 11031, Taiwan.
Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan.
Nutrients. 2018 Sep 22;10(10):1360. doi: 10.3390/nu10101360.
The comprehensive studies done on resveratrol (RES) support that this polyphenol has multiple bioactivities and is widely accepted for dietary supplementation. Furthermore, regular exercise is known to have benefits on health and is considered as a form of preventive medicine. Although the vast majority of prior studies emphasize the efficacy of aerobic exercise in promoting physiological adaptions, other types of exercise, such as resistance exercise and high-intensity interval training (HIIT), may achieve similar or different physiological outcomes. Few studies have looked into the effectiveness of a combinational, synergistic approach to exercise using a weight-loading ladder climbing animal platform. In this study, ICR mice were allocated randomly to the RES and training groups using a two-way ANOVA (RES × Training) design. Exercise capacities, including grip strength, aerobic performance, and anaerobic performance, were assessed and the physiological adaptions were evaluated using fatigue-associated indexes that were implemented immediately after the exercise intervention. In addition, glycogen levels, muscular characteristics, and safety issues, including body composition, histopathology, and biochemistry, were further elucidated. Synergistic effects were observed on grip strength, anaerobic capacities, and exercise lactate, with significant interaction effects. Moreover, the training or RES may have contributed significantly to elevating aerobic capacity, tissue glycogen, and muscle hypertrophy. Toxic and other deleterious effects were also considered to evaluate the safety of the intervention. Resistance exercise in combination with resveratrol supplementation may be applied in the general population to achieve better physiological benefits, promote overall health, and promote participation in regular physical activities.
关于白藜芦醇（RES）的综合研究表明，这种多酚具有多种生物活性，并且广泛用于膳食补充。此外，有规律的运动对健康有益，被认为是一种预防医学形式。尽管绝大多数先前的研究强调有氧运动在促进生理适应方面的功效，但其他类型的运动，如抗阻运动和高强度间歇训练（HIIT），可能会达到相似或不同的生理效果。很少有研究关注使用负重梯式动物平台的组合、协同运动方法的有效性。在这项研究中，我使用双向 ANOVA（RES × Training）设计将 ICR 小鼠随机分配到 RES 和训练组。通过评估握力、有氧性能和无氧性能等运动能力，以及使用运动干预后立即实施的与疲劳相关的指标来评估生理适应。此外，还进一步阐明了糖原水平、肌肉特征以及包括身体成分、组织病理学和生物化学在内的安全性问题。在握力、无氧能力和运动乳酸方面观察到协同作用，具有显著的相互作用效应。此外，训练或 RES 可能显著提高有氧能力、组织糖原和肌肉肥大。还考虑了毒性和其他有害作用，以评估干预的安全性。将抗阻运动与白藜芦醇补充相结合，可能适用于一般人群，以获得更好的生理益处，促进整体健康，并促进定期进行身体活动。
