纳武利尤单抗治疗晚期转移性非小细胞肺癌的日本患者：疗效和安全性临床试验证据的综述。
Nivolumab for the treatment of Japanese patients with advanced metastatic non-small cell lung cancer: a review of clinical trial evidence for efficacy and safety.
机构信息
Aichi Cancer Center Hospital, 1-1, Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.
出版信息
Ther Adv Respir Dis. 2018 Jan-Dec;12:1753466618801167. doi: 10.1177/1753466618801167.
Abstract
Programmed cell death (PD)-1 immune checkpoint inhibitors have emerged as promising options for the treatment of multiple cancer types. Nivolumab is a fully human immunoglobulin G4 monoclonal antibody, which inhibits the PD-1 receptor and has been approved in the United States, Europe, and Asia for the treatment of advanced NSCLC. This review focuses on nivolumab's efficacy and safety in the treatment of NSCLC patients in Japan.
摘要
程序性细胞死亡（PD）-1免疫检查点抑制剂已成为多种癌症治疗的有前途的选择。尼伏鲁单抗是一种完全人源 IgG4 单克隆抗体，可抑制 PD-1 受体，已在美国、欧洲和亚洲获批用于治疗晚期 NSCLC。本综述重点介绍尼伏鲁单抗在日本治疗 NSCLC 患者中的疗效和安全性。
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