Kim K, Mah C, Dominquez J
Diagn Cytopathol. 1986 Dec;2(4):343-6. doi: 10.1002/dc.2840020415.
Pulmonary carcinoid tumors presenting as peripheral or coin lesions are rare and radiologically may resemble other primary or metastatic neoplasms in the lung. This study consisted of the cytologic evaluation of fine-needle aspirates from five peripheral carcinoid tumors of the lung with particular reference to the differences between the cytologic manifestations of this neoplasm and of small-cell carcinoma and well-differentiated adenocarcinoma. Aspirates of typical carcinoid tumors are characterized by isolated cells and loose aggregates of cells; spindle- and oval-shaped cells of uniform size with scanty, pale eosinophilic cytoplasm; and nuclei with evenly dispersed finely granular chromatin and usually prominent single micronucleoli with occasional macronucleoli. In contrast, the cells of small-cell carcinoma are pleomorphic and arranged in noncohesive loose aggregates, their cytoplasm is scanty, and they show nuclear molding. Their nuclei are hyperchromatic with fine to coarsely granular chromatin. The cells of well-differentiated adenocarcinoma are arranged in three-dimensional clusters or loose aggregates of relatively uniform cells with a columnar configuration. The nuclei are uniformly round and hyperchromatic with finely granular chromatin. Macronucleoli are usually prominent. This study demonstrates that cytologic analysis of fine-needle aspirates can play a significant role in the evaluation and management of peripheral lung tumors.
表现为外周型或类圆形病灶的肺类癌肿瘤较为罕见，在放射学上可能类似于肺部的其他原发性或转移性肿瘤。本研究对5例肺外周类癌肿瘤的细针穿刺抽吸物进行了细胞学评估，特别关注了该肿瘤与小细胞癌和高分化腺癌在细胞学表现上的差异。典型类癌肿瘤的抽吸物特征为单个细胞和松散的细胞聚集体；大小均匀的梭形和椭圆形细胞，胞质稀少、淡嗜酸性；细胞核染色质呈细颗粒状均匀分布，通常有明显的单个微核仁，偶尔可见大核仁。相比之下，小细胞癌的细胞多形性，排列成无黏附性的松散聚集体，胞质稀少，可见核膜内陷。其细胞核染色质呈细颗粒状至粗颗粒状，深染。高分化腺癌的细胞排列成三维细胞簇或相对均匀的柱状细胞松散聚集体。细胞核均匀圆形，深染，染色质呈细颗粒状。通常可见明显的大核仁。本研究表明，细针穿刺抽吸物的细胞学分析在外周型肺肿瘤的评估和管理中可发挥重要作用。
