Collins B T, Cramer H M
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA.
Acta Cytol. 1996 Jul-Aug;40(4):695-707. doi: 10.1159/000333942.
To define the cytomorphologic features of carcinoid tumor.
The study consisted of 19 carcinoid tumors sampled by fine needle aspiration. These included 6 pulmonary carcinoids. 11 intestinal carcinoids and 2 aspirates from a patient with a mediastinal carcinoid. The cytomorphologic features of carcinoid tumor were documented, and, in selected cases, immunocytochemical findings were noted. Additionally, the cytology literature concerning carcinoid tumor was reviewed and summarized.
Morphologically, the carcinoid tumors consisted predominantly of loose groups with a background of single cells. A striking degree of cellular and nuclear monomorphism was seen in all cases. Nuclei were small and round to oval, and all exhibited a characteristic finely granular, evenly distributed chromatin pattern. Cytoplasm was minimal to moderate in amount and finely granular in appearance. Necrosis and prominent nucleoli were not seen. Positive staining was noted in all seven cases in which immunostaining for chromogranin was performed. Neuron-specific enolase was positive in four of five cases.
The cytomorphologic characteristics of carcinoid tumors are distinctive, and appropriate ancillary studies can assist in confirming the diagnosis.
明确类癌肿瘤的细胞形态学特征。
本研究包括19例通过细针穿刺取样的类癌肿瘤。其中有6例肺类癌、11例肠类癌以及1例纵隔类癌患者的2份穿刺样本。记录类癌肿瘤的细胞形态学特征，并在部分病例中记录免疫细胞化学结果。此外，对有关类癌肿瘤的细胞学文献进行了回顾和总结。
形态学上，类癌肿瘤主要由散在的细胞群组成，背景为单个细胞。所有病例均可见显著程度的细胞和核单一性。细胞核小，呈圆形至椭圆形，均呈现出特征性的细颗粒状、均匀分布的染色质模式。细胞质数量极少至中等，外观呈细颗粒状。未见坏死和明显核仁。在进行嗜铬粒蛋白免疫染色的所有7例病例中均观察到阳性染色。神经元特异性烯醇化酶在5例中的4例呈阳性。
类癌肿瘤的细胞形态学特征独特，适当的辅助检查有助于确诊。
