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Rifampin Resistance in Staphylococci after Rifaximin Intake for Surgical Prophylaxis in Elective Colorectal Surgery.利福昔明用于择期结直肠手术的外科预防后葡萄球菌的利福平耐药性。
Antimicrob Agents Chemother. 2018 Nov 26;62(12). doi: 10.1128/AAC.01353-18. Print 2018 Dec.
2
Rifaximin intake leads to emergence of rifampin-resistant staphylococci.利福昔明摄入会导致耐利福平葡萄球菌的出现。
J Infect. 2011 Jan;62(1):34-8. doi: 10.1016/j.jinf.2010.11.004. Epub 2010 Nov 10.
3
Activity of Rifampin, Rifabutin, Rifapentine, and Rifaximin against Planktonic and Biofilm States of Staphylococci Isolated from Periprosthetic Joint Infection.利福平、利福布汀、利福喷汀和利福昔明对来自人工关节感染的浮游和生物膜状态葡萄球菌的活性。
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Emergence of rifampin-resistant staphylococci after rifaximin administration in cirrhotic patients.在肝硬化患者中使用利福昔明后出现耐利福平葡萄球菌。
PLoS One. 2017 Oct 5;12(10):e0186120. doi: 10.1371/journal.pone.0186120. eCollection 2017.
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Alteration of staphylococcal flora in cardiac surgery patients receiving antibiotic prophylaxis.接受抗生素预防治疗的心脏手术患者葡萄球菌菌群的改变。
J Infect Dis. 1983 Apr;147(4):642-9. doi: 10.1093/infdis/147.4.642.
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Rifaximin may induce rifampicin resistance in coagulase-negative staphylococci.利福昔明可能会诱导凝固酶阴性葡萄球菌产生对利福平的耐药性。
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Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission.在临床入院前后从马皮肤分离出的葡萄球菌属中存在赋予抗生素抗性的新型mecA和mph(C)变体。
J Clin Microbiol. 2006 Dec;44(12):4444-54. doi: 10.1128/JCM.00868-06. Epub 2006 Sep 27.
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Long-term studies of the effect of rifampin on nasal carriage of coagulase-positive staphylococci.利福平对凝固酶阳性葡萄球菌鼻腔携带影响的长期研究。
Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S459-62. doi: 10.1093/clinids/5.supplement_3.s459.
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Treating animal bites: susceptibility of Staphylococci from oral mucosa of cats.治疗动物咬伤：猫口腔黏膜葡萄球菌的易感性
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Patterns of multidrug resistance among methicillin-resistant hospital isolates of coagulase-positive and coagulase-negative staphylococci collected in the international multicenter study RESIST in 1997 and 1998.1997年和1998年在国际多中心研究RESIST中收集的凝固酶阳性和凝固酶阴性葡萄球菌的耐甲氧西林医院分离株中的多重耐药模式。
Microb Drug Resist. 2000 Fall;6(3):199-211. doi: 10.1089/mdr.2000.6.199.

引用本文的文献

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Diverticular Disease and Rifaximin: An Evidence-Based Review.憩室病与利福昔明：一项基于证据的综述。
Antibiotics (Basel). 2023 Feb 23;12(3):443. doi: 10.3390/antibiotics12030443.
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Increased rate of enteric bacteria as cause of periprosthetic joint infections in patients with liver cirrhosis.肝硬化患者中肠细菌导致假体周围关节感染的发生率增加。
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Antimicrobial Susceptibilities of Clostridium difficile Isolates from 12 Asia-Pacific Countries in 2014 and 2015.2014 年和 2015 年来自亚太地区 12 个国家的艰难梭菌分离株的抗菌药敏性。
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本文引用的文献

1
Emergence of rifampin-resistant staphylococci after rifaximin administration in cirrhotic patients.在肝硬化患者中使用利福昔明后出现耐利福平葡萄球菌。
PLoS One. 2017 Oct 5;12(10):e0186120. doi: 10.1371/journal.pone.0186120. eCollection 2017.
2
Rifampin-Resistant Staphylococcus aureus Bacteremia in a Patient on Chronic Rifaximin.长期服用利福昔明的患者发生耐利福平金黄色葡萄球菌菌血症
Ann Pharmacother. 2017 Jul;51(7):617-618. doi: 10.1177/1060028017701221. Epub 2017 Mar 20.
3
Repeat Rifaximin for Irritable Bowel Syndrome: No Clinically Significant Changes in Stool Microbial Antibiotic Sensitivity.利福昔明重复治疗肠易激综合征：粪便微生物对抗生素的敏感性无临床显著变化。
Dig Dis Sci. 2017 Sep;62(9):2455-2463. doi: 10.1007/s10620-017-4598-7. Epub 2017 Jun 6.
4
Antimicrobial Susceptibility of Staphylococcus Isolates from the Skin of Patients with Diarrhea-Predominant Irritable Bowel Syndrome Treated with Repeat Courses of Rifaximin.接受利福昔明重复疗程治疗的腹泻型肠易激综合征患者皮肤分离出的葡萄球菌的抗菌药敏性
Antimicrob Agents Chemother. 2016 Dec 27;61(1). doi: 10.1128/AAC.02165-16. Print 2017 Jan.
5
Use of rifaximin in gastrointestinal and liver diseases.利福昔明在胃肠道和肝脏疾病中的应用。
World J Gastroenterol. 2016 Aug 7;22(29):6638-51. doi: 10.3748/wjg.v22.i29.6638.
6
Bacteraemia with rifampin-resistant Staphylococcus aureus and the potential role of cross-resistance between rifampin and rifaximin.耐利福平金黄色葡萄球菌菌血症及利福平和利福昔明之间交叉耐药的潜在作用。
J Infect. 2014 Sep;69(3):295-7. doi: 10.1016/j.jinf.2014.04.003. Epub 2014 Apr 26.
7
Rifaximin intake leads to emergence of rifampin-resistant staphylococci.利福昔明摄入会导致耐利福平葡萄球菌的出现。
J Infect. 2011 Jan;62(1):34-8. doi: 10.1016/j.jinf.2010.11.004. Epub 2010 Nov 10.
8
Resistance to rifampicin: at the crossroads between ecological, genomic and medical concerns.利福平耐药性：生态、基因组和医学关注点的十字路口。
Int J Antimicrob Agents. 2010 Jun;35(6):519-23. doi: 10.1016/j.ijantimicag.2009.12.017. Epub 2010 Feb 24.
9
Rifaximin: a novel nonabsorbed rifamycin for gastrointestinal disorders.利福昔明：一种用于胃肠道疾病的新型非吸收性利福霉素。
Clin Infect Dis. 2006 Feb 15;42(4):541-7. doi: 10.1086/499950. Epub 2006 Jan 17.
10
Oral treatment of Staphylococcus spp. infected orthopaedic implants with fusidic acid or ofloxacin in combination with rifampicin.用夫西地酸或氧氟沙星联合利福平对感染葡萄球菌属的骨科植入物进行口服治疗。
J Antimicrob Chemother. 1997 Feb;39(2):235-40. doi: 10.1093/jac/39.2.235.

利福昔明用于择期结直肠手术的外科预防后葡萄球菌的利福平耐药性。

Rifampin Resistance in Staphylococci after Rifaximin Intake for Surgical Prophylaxis in Elective Colorectal Surgery.

机构信息

Microbiology Laboratory, CATLAB, Viladecavalls, Spain

Surgery Service, Hospital de Terrassa (Consorci Sanitari de Terrassa), Terrassa, Spain.

出版信息

Antimicrob Agents Chemother. 2018 Nov 26;62(12). doi: 10.1128/AAC.01353-18. Print 2018 Dec.

DOI:10.1128/AAC.01353-18
PMID:30249689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6256800/
Abstract

The aim of our study was to determine whether rifampin resistance emerges in human skin staphylococci after oral intake of rifaximin for surgical prophylaxis. Rifampin-resistant staphylococci appeared on the skin of 32 out of 74 patients (43.2%) two weeks after prophylactic treatment with rifaximin. In all cases, the resistant strains were coagulase-negative staphylococci. The resistance completely reverted after three months. This study shows the emergence of transient resistance to rifampin after rifaximin intake.

摘要

我们的研究目的是确定利福昔明口服用于手术预防时，是否会导致人类皮肤葡萄球菌产生耐药性。在利福昔明预防性治疗 2 周后，74 例患者中有 32 例（43.2%）的皮肤出现了耐利福平的葡萄球菌。所有耐药菌株均为凝固酶阴性葡萄球菌。三个月后，耐药性完全逆转。本研究表明，利福昔明摄入后会出现短暂的耐利福平现象。