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利福昔明用于择期结直肠手术的外科预防后葡萄球菌的利福平耐药性。

Rifampin Resistance in Staphylococci after Rifaximin Intake for Surgical Prophylaxis in Elective Colorectal Surgery.

机构信息

Microbiology Laboratory, CATLAB, Viladecavalls, Spain

Surgery Service, Hospital de Terrassa (Consorci Sanitari de Terrassa), Terrassa, Spain.

出版信息

Antimicrob Agents Chemother. 2018 Nov 26;62(12). doi: 10.1128/AAC.01353-18. Print 2018 Dec.

Abstract

The aim of our study was to determine whether rifampin resistance emerges in human skin staphylococci after oral intake of rifaximin for surgical prophylaxis. Rifampin-resistant staphylococci appeared on the skin of 32 out of 74 patients (43.2%) two weeks after prophylactic treatment with rifaximin. In all cases, the resistant strains were coagulase-negative staphylococci. The resistance completely reverted after three months. This study shows the emergence of transient resistance to rifampin after rifaximin intake.

摘要

我们的研究目的是确定利福昔明口服用于手术预防时,是否会导致人类皮肤葡萄球菌产生耐药性。在利福昔明预防性治疗 2 周后,74 例患者中有 32 例(43.2%)的皮肤出现了耐利福平的葡萄球菌。所有耐药菌株均为凝固酶阴性葡萄球菌。三个月后,耐药性完全逆转。本研究表明,利福昔明摄入后会出现短暂的耐利福平现象。

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