Microbiology Laboratory, CATLAB, Viladecavalls, Spain
Surgery Service, Hospital de Terrassa (Consorci Sanitari de Terrassa), Terrassa, Spain.
Antimicrob Agents Chemother. 2018 Nov 26;62(12). doi: 10.1128/AAC.01353-18. Print 2018 Dec.
The aim of our study was to determine whether rifampin resistance emerges in human skin staphylococci after oral intake of rifaximin for surgical prophylaxis. Rifampin-resistant staphylococci appeared on the skin of 32 out of 74 patients (43.2%) two weeks after prophylactic treatment with rifaximin. In all cases, the resistant strains were coagulase-negative staphylococci. The resistance completely reverted after three months. This study shows the emergence of transient resistance to rifampin after rifaximin intake.
我们的研究目的是确定利福昔明口服用于手术预防时,是否会导致人类皮肤葡萄球菌产生耐药性。在利福昔明预防性治疗 2 周后,74 例患者中有 32 例(43.2%)的皮肤出现了耐利福平的葡萄球菌。所有耐药菌株均为凝固酶阴性葡萄球菌。三个月后,耐药性完全逆转。本研究表明,利福昔明摄入后会出现短暂的耐利福平现象。