Masumoto Natsuko, Tezuka Junichiro, Nanishi Makiko, Matsuzaki Hiroshi, Nakayama Hideki, Koto Eiko, Kishikawa Reiko
Department of Pediatrics, National Fukuoka Higashi Medical Center.
Department of Allergology and Respiratory Medicine, Fukuoka Children's Hospital.
Arerugi. 2018;67(8):1027-1032. doi: 10.15036/arerugi.67.1027.
We report the case of a boy with a history of atopic dermatitis starting in infancy. At the age of four, his family moved into a newly built house at the foot of a mountain. One year later, he was diagnosed with Japanese Cedar pollinosis. During the same year, in March, he began to experience oral symptoms, hoarseness, and coughing, after eating multiple types of fruits and vegetables, like soybeans, apples, etc. His tests for Bet v1 and the pathogenesis-related protein-10 (PR-10) of the corresponding foods were positive; accordingly, he was diagnosed with Pollen Food Allergy Syndrome (PFAS). In order to investigate the relationship between pollen and food allergies, we counted the pollen grains dispersed at the patient's house during a period of one year and measured his specific IgE titers for pollen and food allergens every three months. We found a large amount of Japanese cedar, cypress, oak, and various other species of pollen dispersed at the patient's house. All counts were higher than the average pollen counts in the city of Fukuoka. After the seasonal dispersal of oak pollen, the patient's specific IgE antibody titers against Alder, Oak, Bet v1, Gly m4, and PR-10 protein group of fruits increased, although alder pollen was not detected. We thus inferred that the patient had developed PFAS by exposure to a large amount of Fagales species pollen, including oak.
我们报告了一名自婴儿期就患有特应性皮炎的男孩的病例。四岁时，他的家人搬到了山脚下的一栋新建房屋中。一年后，他被诊断出患有日本柳杉花粉症。同年3月，他在食用多种水果和蔬菜（如大豆、苹果等）后开始出现口腔症状、声音嘶哑和咳嗽。他对相应食物的Bet v1和病程相关蛋白10（PR - 10）检测呈阳性；因此，他被诊断为花粉食物过敏综合征（PFAS）。为了研究花粉与食物过敏之间的关系，我们在一年的时间里对患者家中飘散的花粉颗粒进行了计数，并每三个月测量他对花粉和食物过敏原的特异性IgE滴度。我们发现患者家中飘散着大量的日本柳杉、柏树、橡树和其他各种花粉。所有计数均高于福冈市的平均花粉计数。在橡树花粉季节性飘散后，患者针对桤木、橡树、Bet v1、Gly m4和水果的PR - 10蛋白组的特异性IgE抗体滴度升高，尽管未检测到桤木花粉。因此，我们推断该患者因接触包括橡树在内的大量壳斗目物种花粉而患上了PFAS。
