Kuan Y F, Scholfield C N
Eur J Pharmacol. 1986 Nov 4;130(3):273-8. doi: 10.1016/0014-2999(86)90278-5.
Slices of guinea-pig olfactory cortex have been used to compare the potency of various Ca-blockers on the electrophysiology of synaptic transmission. Listed in the order of potency, the divalent cations Cd2+, Ni2+, Mn2+, Co2+, La3+ and Mg2+ depressed synaptic transmission. The organic Ca-blockers, nifedipine or nimodipine or verapamil and diltiazem were ineffective up to 0.01 mmol/l. Verapamil, D600 or diltiazem (0.1-0.3 mmol/l) depressed both synaptic transmission and the sodium-mediated presynaptic action potential. These results reaffirm the idea that 'organic Ca-antagonist' do not block all Ca-channels in brain and the high Cd2+ sensitivity suggests the Ca-channels in post- and presynaptic membranes have dissimilar pharmacological profiles.
豚鼠嗅觉皮层切片已被用于比较各种钙阻滞剂对突触传递电生理学的作用强度。按作用强度顺序排列，二价阳离子Cd2+、Ni2+、Mn2+、Co2+、La3+和Mg2+抑制突触传递。有机钙阻滞剂硝苯地平、尼莫地平、维拉帕米和地尔硫䓬在浓度高达0.01 mmol/l时无效。维拉帕米、D600或地尔硫䓬（0.1 - 0.3 mmol/l）抑制突触传递和钠介导的突触前动作电位。这些结果再次证实了“有机钙拮抗剂”不会阻断脑中所有钙通道的观点，并且高Cd2+敏感性表明突触后和突触前膜中的钙通道具有不同的药理学特征。
