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个体化职业康复安置和支持在首发精神病中的应用:一项随机对照试验。

Individual placement and support for vocational recovery in first-episode psychosis: randomised controlled trial.

机构信息

Professor of Functional Recovery in Youth Mental Health, Orygen, The National Centre of Excellence in Youth Mental Health and Centre for Youth Mental Health, The University of Melbourne, Australia.

Senior Research Fellow, Orygen, The National Centre of Excellence in Youth Mental Health and Centre for Youth Mental Health, The University of Melbourne, Australia.

出版信息

Br J Psychiatry. 2019 Feb;214(2):76-82. doi: 10.1192/bjp.2018.191. Epub 2018 Sep 25.

Abstract

BACKGROUND

High unemployment is a hallmark of psychotic illness. Individual placement and support (IPS) may be effective at assisting the vocational recoveries of young people with first-episode psychosis (FEP).AimsTo examine the effectiveness of IPS at assisting young people with FEP to gain employment (Australian and Clinical Trials Registry ACTRN12608000094370).

METHOD

Young people with FEP (n = 146) who were interested in vocational recovery were randomised using computer-generated random permuted blocks on a 1:1 ratio to: (a) 6 months of IPS in addition to treatment as usual (TAU) or (b) TAU alone. Assessments were conducted at baseline, 6 months (end of intervention), 12 months and 18 months post-baseline by research assistants who were masked to the treatment allocations.

RESULTS

At the end of the intervention the IPS group had a significantly higher rate of having been employed (71.2%) than the TAU group (48.0%), odds ratio 3.40 (95% CI 1.17-9.91, z = 2.25, P = 0.025). However, this difference was not seen at 12- and 18-month follow-up points. There was no difference at any time point on educational outcomes.

CONCLUSIONS

This is the largest trial to our knowledge on the effectiveness of IPS in FEP. The IPS group achieved a very high employment rate during the 6 months of the intervention. However, the advantage of IPS was not maintained in the long term. This seems to be related more to an unusually high rate of employment being achieved in the control group rather than a gross reduction in employment among the IPS group.Declaration of interestNone.

摘要

背景

高失业率是精神病的一个显著特征。个体安置与支持(IPS)可能对帮助首次发作精神分裂症(FEP)的年轻人恢复职业有效果。

目的

研究 IPS 对帮助 FEP 年轻人获得就业的效果(澳大利亚临床试验注册中心 ACTRN12608000094370)。

方法

对有职业康复意愿的 FEP 年轻人(n = 146)按 1:1 的比例随机分配至 IPS 加常规治疗组(TAU)或 TAU 组,使用计算机生成的随机区组进行分配。研究助理在基线、6 个月(干预结束)、12 个月和 18 个月时进行评估,对治疗分配不知情。

结果

干预结束时,IPS 组的就业率(71.2%)显著高于 TAU 组(48.0%),优势比 3.40(95% CI 1.17-9.91,z = 2.25,P = 0.025)。但在 12 个月和 18 个月的随访中未观察到这一差异。在任何时间点,两组在教育结果上都没有差异。

结论

这是我们所知的 IPS 在 FEP 中效果的最大规模试验。IPS 组在干预的 6 个月内实现了非常高的就业率。然而,IPS 的优势并没有在长期内持续。这似乎更多与对照组中异常高的就业率有关,而不是 IPS 组的就业率大幅下降。

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