Tandukar Srijan, Hariharan Sundaram
a Division of Transplant Nephrology , University of Pittsburgh Medical Center , Pittsburgh , PA , USA.
Organogenesis. 2018;14(4):159-162. doi: 10.1080/15476278.2018.1517508. Epub 2018 Sep 25.
The transplantation of living cells, tissues or organs from one species to another is termed xenotransplantation. The history of xenotransplantation is as old as allogeneic transplantation itself. Early attempts were made at a time when the immunologic basis of organ rejection were poorly understood. The advent of potent immunosuppressive medications along with the parallel advances in the field of genetic engineering has provided a fresh perspective on the role of xenotransplantation as a means to alleviate the disparity between the number of candidates on the waitlist and the available organs. As the science behind xenotransplantation advances, the transplantation community must take it upon themselves to educate the community at large regarding both the benefits and potential risks of this promising field.
将活细胞、组织或器官从一个物种移植到另一个物种被称为异种移植。异种移植的历史与同种异体移植本身一样悠久。早期尝试是在人们对器官排斥的免疫学基础了解甚少的时候进行的。强效免疫抑制药物的出现以及基因工程领域的同步进展，为异种移植作为缓解等待名单上的候选者数量与可用器官之间差距的一种手段的作用提供了新的视角。随着异种移植背后的科学不断进步，移植界必须自行承担起责任，向广大公众普及这个有前景领域的益处和潜在风险。
