a Department of Nutrition , Nutritional Health Research Center, Lorestan University of Medical Sciences , Khorramabad , Iran.
b Department of Nutrition , Nutrition and Metabolic Diseases Researcher Center, Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.
J Am Coll Nutr. 2019 May-Jun;38(4):327-333. doi: 10.1080/07315724.2018.1510349. Epub 2018 Sep 25.
A high prevalence of vitamin D deficiency (VDD) in gastrointestinal (GI) disorders and the role of vitamin D in the function of the gut have been shown previously. Therefore, we aimed to evaluated the VDD and the possible association of the GI symptoms severity and quality of life (QoL) score with the serum levels of vitamin D in irritable bowel syndrome (IBS).
A total of 90 patients with IBS based on Rome III criteria enrolled in the study from the tertiary referral university hospital. In addition, 90 sex- and age-matched healthy controls (HCs) were recruited. To measure the serum levels of 25(OH)D, blood samples were taken from all the participants. Severity of clinical symptoms, IBS quality of life (IBS-QoL), and IBS symptom severity score (IBSSS) were assessed.
In 66.7% of IBS patients, serum 25(OH)D concentrations were <20 ng/mL. The mean serum 25(OH)D of IBS patients was statistically (p < 0.05) lower vs. HCs. When different subtypes were analyzed, the serum 25(OH)D concentrations in diarrhea-predominant IBS were statistically (p < 0.05) lower as compared to HCs. Furthermore, the lower serum concentrations of 25(OH)D were associated (p < 0.05) with higher severity of abdominal pain and distention, flatulence, overall GI symptoms, and IBSSS. However, a direct significant association was seen between IBS-QoL and serum 25(OH)D.
Results of this study showed a high prevalence of VDD in patients with IBS. In addition, VDD was associated with a higher severity of clinical symptoms and lower QoL in IBS.
先前已经表明，胃肠道（GI）疾病中维生素 D 缺乏（VDD）的患病率较高，维生素 D 在肠道功能中的作用。因此，我们旨在评估 VDD，以及 GI 症状严重程度和生活质量（QoL）评分与肠易激综合征（IBS）患者血清维生素 D 水平之间的可能关联。
本研究共纳入了 90 名符合 Rome III 标准的 IBS 患者，并从三级转诊大学医院招募了 90 名性别和年龄匹配的健康对照者（HCs）。为了测量血清 25（OH）D 水平，从所有参与者中抽取了血样。评估了临床症状的严重程度、IBS 生活质量（IBS-QoL）和 IBS 症状严重程度评分（IBSSS）。
在 66.7%的 IBS 患者中，血清 25（OH）D 浓度<20ng/mL。IBS 患者的平均血清 25（OH）D 水平与 HCs 相比具有统计学意义（p<0.05）。当分析不同的亚型时，腹泻型 IBS 患者的血清 25（OH）D 浓度与 HCs 相比具有统计学意义（p<0.05）。此外，较低的血清 25（OH）D 浓度与更高的腹痛和腹胀严重程度、气胀、整体 GI 症状和 IBSSS 相关（p<0.05）。然而，IBS-QoL 与血清 25（OH）D 之间存在直接显著的关联。
本研究结果表明，IBS 患者中 VDD 的患病率较高。此外，VDD 与 IBS 患者更严重的临床症状和更低的 QoL 相关。
