Choghakhori Razieh, Abbasnezhad Amir, Hasanvand Amin, Amani Reza
Nutritional Health Research Center, Department of Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran.
Nutritional Health Research Center, Department of Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran; Nutrition and Metabolic Diseases Researcher Center, Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Cytokine. 2017 May;93:34-43. doi: 10.1016/j.cyto.2017.05.005. Epub 2017 May 12.
A growing body of evidence suggests a possible role for low-grade inflammation in the pathogenesis of irritable bowel syndrome (IBS). The objectives of this study were to measure serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-17, interleukin (IL)-10, malondialdehyde (MDA) and total antioxidant capacity (TAC) in IBS patients and healthy controls (HCs), and to evaluate possible correlations of such markers with gastrointestinal (GI) symptoms and quality of life (QoL). Ninety Rome III positive IBS patients and 90 sex and age matched HCs were recruited. GI symptoms, IBS-QoL, IBS severity score system (IBSSS), and the serum levels of inflammatory cytokines and oxidative stress biomarkers were evaluated. In IBS patients, TNFα, IL-17 and MDA cytokines were significantly (P<0.05) higher, and IL-10 cytokine and TAC were significantly (P<0.05) lower vs. HCs. When comparing IBS subtypes, TNFα and IL-17 were significantly (P<0.05) higher, and IL-10 was significantly (P<0.05) lower in diarrhea predominant IBS (IBS-D) compared to HCs, whereas the inflammatory cytokine profile of other subtypes more closely resembled that of HCs. The serum levels of MDA and TAC were significantly different (P<0.05) in all the subtypes vs. HCs. All the inflammatory cytokines had significant (P<0.05) correlations with GI symptoms, IBSSS and IBS-QoL, whereas no significant association was found between oxidative stress biomarkers and these symptoms. IBS-D patients display increased pro-inflammatory cytokines and decreased anti-inflammatory cytokines. Present study demonstrated a correlation between inflammatory cytokines and both IBS symptoms and QoL.
越来越多的证据表明，低度炎症在肠易激综合征（IBS）的发病机制中可能起作用。本研究的目的是测量IBS患者和健康对照者（HCs）血清中肿瘤坏死因子（TNF）-α、白细胞介素（IL）-17、白细胞介素（IL）-10、丙二醛（MDA）和总抗氧化能力（TAC）的水平，并评估这些标志物与胃肠道（GI）症状和生活质量（QoL）之间的可能相关性。招募了90名符合罗马III标准的IBS阳性患者和90名年龄和性别匹配的HCs。评估了GI症状、IBS-QoL、IBS严重程度评分系统（IBSSS）以及炎症细胞因子和氧化应激生物标志物的血清水平。与HCs相比，IBS患者的TNFα、IL-17和MDA细胞因子显著升高（P<0.05），而IL-10细胞因子和TAC显著降低（P<0.05）。比较IBS亚型时，与HCs相比，腹泻型IBS（IBS-D）中的TNFα和IL-17显著升高（P<0.05），而IL-10显著降低（P<0.05），而其他亚型的炎症细胞因子谱与HCs更相似。所有亚型的MDA和TAC血清水平与HCs相比均有显著差异（P<0.05）。所有炎症细胞因子与GI症状、IBSSS和IBS-QoL均有显著相关性（P<0.05），而氧化应激生物标志物与这些症状之间未发现显著关联。IBS-D患者表现出促炎细胞因子增加和抗炎细胞因子减少。本研究证明了炎症细胞因子与IBS症状和QoL之间的相关性。
