Mélone J
J Auton Nerv Syst. 1986 Nov;17(3):231-41. doi: 10.1016/0165-1838(86)90060-3.
In anesthetized cats, the unitary activity of 53 sensory vagal neurons was recorded in nodose ganglia by means of extracellular glass microelectrodes. All the neurons had non-medullated fibres, with conduction velocities ranging from 0.8 to 1.2 m/s. Forty of these cells were stimulated by perfusion of the small intestine with lipids. Two types of receptors were identified: 21 endings were activated by glycerol and short chain lipids, and 19 endings were activated by long chain lipids. These receptors did not respond to either mechanical or osmotic stimulation. The discharge frequency generally increased with the concentration. The short latency suggested that they were located close to the enterocyte. The role of vagal intestinal receptors sensitive to lipids is discussed. Their functional characteristics along with previous experimental data suggest that they may be involved in the regulation of gastric emptying and alimentary behaviour, particularly satiety mechanisms.
在麻醉猫身上，用细胞外玻璃微电极在结状神经节记录了53个感觉迷走神经神经元的单位活动。所有神经元都有无髓纤维，传导速度在0.8至1.2米/秒之间。其中40个细胞通过向小肠灌注脂质来刺激。鉴定出两种类型的受体：21个末梢被甘油和短链脂质激活，19个末梢被长链脂质激活。这些受体对机械或渗透压刺激均无反应。放电频率通常随浓度增加。潜伏期短表明它们位于靠近肠上皮细胞的位置。讨论了对脂质敏感的迷走神经肠道受体的作用。它们的功能特性以及先前的实验数据表明，它们可能参与胃排空和进食行为的调节，特别是饱腹感机制。
