Karinja Sarah J, Spector Jason A
From the Division of Plastic Surgery, Weill Cornell Medical College; Columbia University College of Physicians and Surgeons; and the Meinig School of Biomedical Engineering, Cornell University.
Plast Reconstr Surg. 2018 Oct;142(4):1082-1092. doi: 10.1097/PRS.0000000000004799.
As antibiotic resistance increases and antimicrobial options diminish, there is a pressing need to identify and develop new and/or alternative (non-antimicrobial-based) wound therapies. The authors describe the implications of antibiotic resistance on their current wound treatment paradigms and review the most promising non-antibiotic-based antimicrobial agents currently in research and development, with a focus on preclinical and human studies of therapeutic bacteriophages, antimicrobial peptides, cold plasma treatment, photodynamic therapy, honey, silver, and bioelectric dressings.
随着抗生素耐药性增加且抗菌选择减少，迫切需要识别和开发新的和/或替代的（非基于抗生素的）伤口治疗方法。作者描述了抗生素耐药性对其当前伤口治疗模式的影响，并综述了目前正在研发的最有前景的非抗生素类抗菌剂，重点关注治疗性噬菌体、抗菌肽、冷等离子体治疗、光动力疗法、蜂蜜、银和生物电敷料的临床前和人体研究。
