动脉自旋标记 MRI 测量人眼血流灌注的可重复性。
Repeatability of Arterial Spin Labeling MRI in Measuring Blood Perfusion in the Human Eye.
机构信息
School of Optometry and Vision Science, University of Auckland, New Zealand.
Department of Optometry, Asia University, Taichung, Taiwan.
出版信息
J Magn Reson Imaging. 2019 Apr;49(4):966-974. doi: 10.1002/jmri.26323. Epub 2018 Sep 25.
BACKGROUND
Quantifying blood perfusion in ocular tissues is challenging, partly because the majority of the blood is carried by the choroid, which is difficult to visualize because it is located between the retina and sclera.
PURPOSE/HYPOTHESIS: To evaluate the intra- and interday repeatability of MRI measures of chorio-retinal blood perfusion.
STUDY TYPE
Prospective, cross-sectional, observational study.
POPULATION
Twenty young healthy adults (six male, age: 25 ± 5 years) scanned twice within a single session repeated at the same time of day on 2 days.
FIELD STRENGTH/SEQUENCE: Arterial spin labeling (ASL) MRI at 3.0T using pseudocontinuous ASL (PCASL) labeling scheme and a 3D turbo-gradient-spin-echo (TGSE) acquisition, including axial T -weighted structural images using a 2D turbo-spin-echo (TSE) sequence.
ASSESSMENTS
Region-of-interest analysis for assessment of chorio-retinal blood perfusion.
STATISTICAL TESTS
Intra- and interday repeatability of measures analyzed using intraclass correlation coefficients (ICC), Pearson's correlation analysis, paired t-tests, and Bland-Altman plots.
RESULTS
The mean chorio-retinal perfusion was 77.86 (standard deviation [SD] = 29.80) ml/100ml/min. Perfusion measurements correlated strongly within a single session (r = 0.95, 95% confidence interval [CI] [0.880-0.980], P < 0.001) and between the two sessions based on a single run (r = 0.80 [0.582-0.913], P < 0.001), and two runs (r = 0.80 [0.479-0.918], P < 0.001). There were mean differences of 2.69 [16.85 to -22.23] ml/100ml/min for intraday measures, -7.44 [27.45 to -42.32] ml/100ml/min for single-run interday measures, and 5.73 [28.71 to -40.17] ml/100ml/min for two-run interday measures, but none were significant (all P > 0.05).
DATA CONCLUSION
Quantitative ASL-MRI measurements of chorio-retinal blood perfusion showed high intra- and interday repeatability. The ASL-MRI technique provides reliable measures of chorio-retinal perfusion in vivo.
LEVEL OF EVIDENCE
1 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;49:966-974.
背景
定量眼部组织的血液灌注是具有挑战性的，部分原因是大部分血液由脉络膜携带，而脉络膜位于视网膜和巩膜之间，因此很难可视化。
目的/假设：评估 MRI 测量脉络膜视网膜血液灌注的日内和日间重复性。
研究类型
前瞻性、横断面、观察性研究。
人群
20 名年轻健康成年人（6 名男性，年龄：25±5 岁）在同一天的两次扫描，两次扫描在同一天的同一时间进行，两次扫描在两次单独的会议中进行。
场强/序列：3.0T 磁共振成像采用伪连续动脉自旋标记（ASL）（PCASL）标记方案和 3D 涡轮梯度回波自旋回波（TGSE）采集，包括使用二维涡轮自旋回波（TSE）序列进行轴向 T1 加权结构图像。
评估
评估脉络膜视网膜血液灌注的感兴趣区分析。
统计检验
使用组内相关系数（ICC）、皮尔逊相关分析、配对 t 检验和 Bland-Altman 图分析评估测量值的日内和日间重复性。
结果
脉络膜视网膜平均灌注为 77.86（标准偏差[SD]=29.80）ml/100ml/min。单次会话内的灌注测量值相关性很强（r=0.95，95%置信区间[CI] [0.880-0.980]，P<0.001），两次会话之间基于单次运行的相关性也很强（r=0.80 [0.582-0.913]，P<0.001），两次运行之间的相关性也很强（r=0.80 [0.479-0.918]，P<0.001）。日内测量的平均差异为 2.69（16.85 至-22.23）ml/100ml/min，单次运行日间测量的平均差异为-7.44（27.45 至-42.32）ml/100ml/min，两次运行日间测量的平均差异为 5.73（28.71 至-40.17）ml/100ml/min，但均无统计学意义（均 P>0.05）。
数据结论
定量 ASL-MRI 测量脉络膜视网膜血液灌注显示出高度的日内和日间可重复性。ASL-MRI 技术可在体内提供可靠的脉络膜视网膜灌注测量值。
证据水平
1 技术功效阶段：2 J. Magn. Reson. Imaging 2019;49:966-974.
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