Department of Veterinary Medicine (DIMEVET), Università degli Studi di Milano, Via Celoria 10, 20133, Milan, Italy.
Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK, 74078, USA.
Food Chem Toxicol. 2018 Nov;121:666-675. doi: 10.1016/j.fct.2018.09.050. Epub 2018 Sep 22.
Fusarium mycotoxins, such as fumonisins, trichothecenes, zearalenone and emerging fusariotoxins, common contaminants of feed and food, have received increased interest, due to the possible impact on animal and human health. In this context, it is urgent to focus our attention on fusariotoxins adverse effects, considering and analysing data in relation to their species-specificity. The in vitro approach for fusariotoxins risk assessment evaluation, through porcine epithelial barriers model, allowed to collect information on their absorption profile, bioavailability and toxicity. The aim of this review is to give an overview on Fusarium mycotoxins and their interactions with porcine intestinal and brain in vitro barriers, because they represent direct target organs of toxicity and as tools to evaluate their permeability and transport.
镰刀菌真菌毒素，如伏马菌素、单端孢霉烯族化合物、玉米赤霉烯酮和新兴的镰刀菌毒素，是饲料和食品中常见的污染物，由于它们可能对动物和人类健康产生影响，因此受到了越来越多的关注。在这种情况下，我们迫切需要关注镰刀菌毒素的不良反应，考虑并分析与物种特异性相关的数据。通过猪上皮屏障模型进行的体外方法评估镰刀菌毒素风险，可收集有关其吸收情况、生物利用度和毒性的信息。本综述的目的是概述镰刀菌真菌毒素及其与猪肠和脑体外屏障的相互作用，因为它们是毒性的直接靶器官，也是评估其渗透性和运输的工具。
