• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于 1,2,4-三唑的苯并噻唑/苯并恶唑衍生物：设计、合成、p38α MAP 激酶抑制、抗炎活性和分子对接研究。

1,2,4-Triazole-based benzothiazole/benzoxazole derivatives: Design, synthesis, p38α MAP kinase inhibition, anti-inflammatory activity and molecular docking studies.

机构信息

Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.

Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.

出版信息

Bioorg Chem. 2018 Dec;81:630-641. doi: 10.1016/j.bioorg.2018.09.015. Epub 2018 Sep 8.

DOI:10.1016/j.bioorg.2018.09.015
PMID:30253336
Abstract

Novel N-(benzothiazol/oxazol-2-yl)-2-[(5-(phenoxymethyl)-4-aryl-4H-1,2,4-triazol-3-yl)thio] acetamide derivatives (5a-n) were synthesized and investigated for in vitro anti-inflammatory activity and p38α MAP kinase inhibition. Compounds showing good in vitro activities (5a, 5b, 5d, 5e, 5i, 5k and 5l) were studied for their in vivo anti-inflammatory activity using carrageenan induced rat paw edema model. Compound 5b emerged as the most active compound with an edema inhibition of 84.43%. It also showed improved GI safety profile with lower ulcer severity index and lipid peroxidation potential. Also, p38α MAP kinase assay of 5b showed superior inhibitory potency (IC:0.031 ± 0.14 µM) than the standard SB 203580 (IC:0.043 ± 0.14 µM). To predict their binding mode compounds were also docked against p38α MAP kinase enzyme. Compound 5b and SB 203580 showed hinge region interaction with MET 109.

摘要

新型 N-(苯并噻唑/恶唑-2-基)-2-[(5-(苯氧甲基)-4-芳基-4H-1,2,4-三唑-3-基)硫代]乙酰胺衍生物（5a-n）被合成并研究其体外抗炎活性和 p38α MAP 激酶抑制作用。显示出良好体外活性的化合物（5a、5b、5d、5e、5i、5k 和 5l）在角叉菜胶诱导的大鼠足肿胀模型中研究了其体内抗炎活性。化合物 5b 表现出最活跃的活性，其水肿抑制率为 84.43%。它还表现出改善的 GI 安全性特征，具有较低的溃疡严重指数和脂质过氧化潜力。此外，5b 的 p38α MAP 激酶测定显示出优于标准 SB 203580 的抑制效力（IC：0.031±0.14µM）。为了预测它们的结合模式，还将化合物对接至 p38α MAP 激酶酶。化合物 5b 和 SB 203580 与 MET 109 表现出铰链区域相互作用。

相似文献

1
1,2,4-Triazole-based benzothiazole/benzoxazole derivatives: Design, synthesis, p38α MAP kinase inhibition, anti-inflammatory activity and molecular docking studies.基于 1,2,4-三唑的苯并噻唑/苯并恶唑衍生物：设计、合成、p38α MAP 激酶抑制、抗炎活性和分子对接研究。
Bioorg Chem. 2018 Dec;81:630-641. doi: 10.1016/j.bioorg.2018.09.015. Epub 2018 Sep 8.
2
Synthesis, p38α MAP kinase inhibition, anti-inflammatory activity, and molecular docking studies of 1,2,4-triazole-based benzothiazole-2-amines.基于 1,2,4-三唑的苯并噻唑-2-胺的合成、p38α MAP 激酶抑制、抗炎活性及分子对接研究。
Arch Pharm (Weinheim). 2018 Apr;351(3-4):e1700304. doi: 10.1002/ardp.201700304. Epub 2018 Mar 8.
3
Synthesis, anti-inflammatory, p38α MAP kinase inhibitory activities and molecular docking studies of quinoxaline derivatives containing triazole moiety.含三唑基的喹喔啉衍生物的合成、抗炎、p38α MAP 激酶抑制活性及分子对接研究。
Bioorg Chem. 2018 Feb;76:343-358. doi: 10.1016/j.bioorg.2017.12.003. Epub 2017 Dec 2.
4
Synthesis, evaluation and docking of novel pyrazolo pyrimidines as potent p38α MAP kinase inhibitors with improved anti-inflammatory, ulcerogenic and TNF-α inhibitory properties.新型吡唑并嘧啶的合成、评价及对接研究作为强效 p38α MAP 激酶抑制剂，具有改善的抗炎、致溃疡和 TNF-α 抑制特性。
Bioorg Chem. 2019 Jun;87:550-559. doi: 10.1016/j.bioorg.2019.03.037. Epub 2019 Mar 15.
5
Substituted Benzamides from Anti-inflammatory and p38 Kinase Inhibitors to Antitubercular Activity: Design, Synthesis and Screening.取代苯甲酰胺类抗炎 p38 激酶抑制剂的抗结核活性：设计、合成与筛选。
Mini Rev Med Chem. 2018;18(17):1486-1497. doi: 10.2174/1389557517666170707105416.
6
Synthesis, Antifungal Activities and Molecular Docking Studies of Benzoxazole and Benzothiazole Derivatives.苯并恶唑和苯并噻唑衍生物的合成、抗真菌活性及分子对接研究。
Molecules. 2018 Sep 25;23(10):2457. doi: 10.3390/molecules23102457.
7
Design, synthesis, biological evaluation, and in silico studies of quinoxaline derivatives as potent p38α MAPK inhibitors.喹喔啉衍生物作为有效的p38α丝裂原活化蛋白激酶抑制剂的设计、合成、生物学评价及计算机模拟研究
Arch Pharm (Weinheim). 2024 Jan;357(1):e2300301. doi: 10.1002/ardp.202300301. Epub 2023 Oct 17.
8
Aryl/heteroaryl Substituted Celecoxib Derivatives as COX-2 Inhibitors: Synthesis, Anti-inflammatory Activity and Molecular Docking Studies.芳基/杂芳基取代的塞来昔布衍生物作为COX-2抑制剂：合成、抗炎活性及分子对接研究
Med Chem. 2017;13(5):484-497. doi: 10.2174/1573406413666170221093740.
9
Synthesis of novel 2-mercapto benzothiazole and 1,2,3-triazole based bis-heterocycles: their anti-inflammatory and anti-nociceptive activities.新型 2-巯基苯并噻唑和 1,2,3-三唑双杂环的合成：其抗炎和抗伤害感受活性。
Eur J Med Chem. 2012 Mar;49:324-33. doi: 10.1016/j.ejmech.2012.01.032. Epub 2012 Jan 24.
10
Design, synthesis and anti-inflammatory activity of imidazol-5-yl pyridine derivatives as p38α/MAPK14 inhibitor.设计、合成并研究咪唑-5-基吡啶衍生物作为 p38α/MAPK14 抑制剂的抗炎活性。
Bioorg Med Chem. 2021 Feb 1;31:115969. doi: 10.1016/j.bmc.2020.115969. Epub 2020 Dec 28.

引用本文的文献

1
The Spectroscopic Characterization and Photophysical Properties of a Hydrated Lanthanum Ion Complex with a Triazole Ligand by Several DFT Methods.采用多种密度泛函理论方法对水合镧离子与三唑配体配合物的光谱表征及光物理性质研究
Molecules. 2025 Aug 18;30(16):3412. doi: 10.3390/molecules30163412.
2
Design, synthesis and evaluation of benzodioxole and bromofuran tethered 1,2,4-triazole hybrids as potential anti breast cancer agents with computational insights.苯并二恶唑和溴代呋喃连接的1,2,4-三唑杂化物作为潜在抗乳腺癌药物的设计、合成与评估及计算分析
Sci Rep. 2025 Jul 16;15(1):25680. doi: 10.1038/s41598-025-09420-1.
3
Development of Potent Type V MAPK Inhibitors: Design, Synthesis, and Biological Evaluation of Benzothiazole Derivatives Targeting p38α MAPK in Breast Cancer Cells.
强效V型丝裂原活化蛋白激酶抑制剂的开发：针对乳腺癌细胞中p38α丝裂原活化蛋白激酶的苯并噻唑衍生物的设计、合成及生物学评价
Arch Pharm (Weinheim). 2025 Apr;358(4):e2500011. doi: 10.1002/ardp.202500011.
4
Search for New Compounds with Anti-Inflammatory Activity Among 1,2,4-Triazole Derivatives.在1,2,4-三唑衍生物中寻找具有抗炎活性的新化合物。
Molecules. 2024 Dec 21;29(24):6036. doi: 10.3390/molecules29246036.
5
Multitarget Pharmacology of Sulfur-Nitrogen Heterocycles: Anticancer and Antioxidant Perspectives.硫氮杂环化合物的多靶点药理学：抗癌与抗氧化视角
Antioxidants (Basel). 2024 Jul 25;13(8):898. doi: 10.3390/antiox13080898.
6
Design, synthesis, and unraveling the antibacterial and antibiofilm potential of 2-azidobenzothiazoles: insights from a comprehensive study.2-叠氮基苯并噻唑的设计、合成及其抗菌和抗生物膜潜力解析：一项综合研究的见解
Front Chem. 2023 Sep 7;11:1264747. doi: 10.3389/fchem.2023.1264747. eCollection 2023.
7
New Triazinoindole Bearing Benzimidazole/Benzoxazole Hybrids Analogs as Potent Inhibitors of Urease: Synthesis, In Vitro Analysis and Molecular Docking Studies.新型三嗪并吲哚取代苯并咪唑/苯并恶唑杂合体作为有效的脲酶抑制剂：合成、体外分析和分子对接研究。
Molecules. 2022 Oct 4;27(19):6580. doi: 10.3390/molecules27196580.
8
Synthetic Approaches to Biologically Active C-2-Substituted Benzothiazoles.C-2 取代苯并噻唑类生物活性化合物的合成方法。
Molecules. 2022 Apr 18;27(8):2598. doi: 10.3390/molecules27082598.
9
Synthesis of biologically active derivatives of 2-aminobenzothiazole.2-氨基苯并噻唑生物活性衍生物的合成
Chem Heterocycl Compd (N Y). 2021;57(4):369-373. doi: 10.1007/s10593-021-02914-6. Epub 2021 May 12.
10
Modern Approaches to the Synthesis and Transformations of Practically Valuable Benzothiazole Derivatives.现代方法合成与转化实用价值的苯并噻唑衍生物。
Molecules. 2021 Apr 10;26(8):2190. doi: 10.3390/molecules26082190.