在1,2,4-三唑衍生物中寻找具有抗炎活性的新化合物。

Glomb Teresa, Minta Julia, Nowosadko Michalina, Radzikowska Julia, Świątek Piotr

Department of Medicinal Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.

Student Science Club of Medicinal Chemistry, Department of Medicinal Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.

Molecules. 2024 Dec 21;29(24):6036. doi: 10.3390/molecules29246036.

Compounds containing the 1,2,4-triazole moiety in their structure exhibit broad biological activities. Many of these compounds demonstrate anti-inflammatory activity in vitro through various mechanisms, such as inhibiting COX-1/COX-2 and LOX, modulating pro-inflammatory cytokine levels, or having effects on other specific enzymes. Some also display activities in vivo. In many publications, the activities of new 1,2,4-triazole-based compounds exceed those of the reference drugs, suggesting their promising potential as new therapeutic agents. This review of active 1,2,4-triazole derivatives with anti-inflammatory activity is based on literature published from 2015-2024.

结构中含有1,2,4 - 三唑部分的化合物具有广泛的生物活性。这些化合物中的许多通过多种机制在体外表现出抗炎活性，例如抑制COX - 1/COX - 2和LOX、调节促炎细胞因子水平或对其他特定酶产生作用。有些在体内也有活性。在许多出版物中，新型1,2,4 - 三唑类化合物的活性超过了参考药物，表明它们作为新型治疗剂具有广阔的潜力。这篇关于具有抗炎活性的1,2,4 - 三唑衍生物的综述基于2015年至2024年发表的文献。