School of Life Sciences, Northwestern Polytechnical University, Xi'an, China.
National Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China,
J Innate Immun. 2019;11(3):242-248. doi: 10.1159/000492679. Epub 2018 Sep 25.
Cyclic dimeric guanosine monophosphate (c-di-GMP) is a universally conserved second messenger that contributes to the pathogenicity of numerous bacterial species. In recent years, growing evidence has shown that bacterial extracellular c-di-GMP can interact with the innate immune system and regulate host immune responses. This review summarizes our current understanding on the dual roles of bacterial c-di-GMP in pathogen-host interaction: activation of the antibacterial innate immune response through the cytosolic surveillance pathway and inhibition of innate immune defense for iron restriction.
环二鸟苷酸（cyclic dimeric guanosine monophosphate，c-di-GMP）是一种普遍存在的第二信使，有助于许多细菌物种的致病性。近年来，越来越多的证据表明，细菌细胞外的 c-di-GMP 可以与先天免疫系统相互作用，并调节宿主的免疫反应。本综述总结了我们目前对细菌 c-di-GMP 在病原体-宿主相互作用中的双重作用的理解：通过细胞质监测途径激活抗菌先天免疫反应，以及抑制先天免疫防御以限制铁的摄取。
