Galli Carlo, Pedrazzi Giuseppe, Mattioli-Belmonte Monica, Guizzardi Stefano
Dep. of Medicine and Surgery, University of Parma, Italy.
DISCLIMO, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.
Int J Biomater. 2018 Sep 3;2018:8935750. doi: 10.1155/2018/8935750. eCollection 2018.
Implantable biomaterials are extensively used to promote bone regeneration or support endosseous prosthesis in orthopedics and dentistry. Their use, however, would benefit from additional strategies to improve bone responses. Pulsed Electromagnetic Fields (PEMFs) have long been known to act on osteoblasts and bone, affecting their metabolism, in spite of our poor understanding of the underlying mechanisms. Hence, we have the hypothesis that PEMFs may also ameliorate cell responses to biomaterials, improving their growth, differentiation, and the expression of a mature phenotype and therefore increasing the tissue integration of the implanted devices and their clinical success. A broad range of settings used for PEMFs stimulation still represents a hurdle to better define treatment protocols and extensive research is needed to overcome this issue. The present review includes studies that investigated the effects of PEMFs on the response of bone cells to different classes of biomaterials and the reports that focused on in vivo investigations of biomaterials implanted in bone.
可植入生物材料在骨科和牙科中广泛用于促进骨再生或支持骨内假体。然而，它们的应用将受益于其他改善骨反应的策略。长期以来，人们一直知道脉冲电磁场（PEMF）作用于成骨细胞和骨骼，影响它们的代谢，尽管我们对其潜在机制了解甚少。因此，我们有这样的假设，即脉冲电磁场也可能改善细胞对生物材料的反应，促进其生长、分化以及成熟表型的表达，从而提高植入装置的组织整合及其临床成功率。用于脉冲电磁场刺激的广泛设置仍然是更好地定义治疗方案的一个障碍，需要进行广泛的研究来克服这个问题。本综述包括研究脉冲电磁场对骨细胞对不同类型生物材料反应的影响的研究，以及专注于对植入骨内的生物材料进行体内研究的报告。
