通过烯胺酮与对甲苯磺酰叠氮的水介导环加成反应无催化剂合成4-酰基-1,2,3-三唑。
Catalyst-free synthesis of 4-acyl--1,2,3-triazoles by water-mediated cycloaddition reactions of enaminones and tosyl azide.
作者信息
Yang Lu, Wu Yuwei, Yang Yiming, Wen Chengping, Wan Jie-Ping
机构信息
College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China.
College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, P. R. China.
出版信息
Beilstein J Org Chem. 2018 Sep 7;14:2348-2353. doi: 10.3762/bjoc.14.210. eCollection 2018.
The synthesis of 4-acyl--1,2,3-triazoles has been accomplished with high efficiency through the cycloaddition reactions between -dimethylenaminones and tosyl azide. This method is featured with extraordinary sustainability by employing water as the sole medium, free of any catalyst or additive, authentically mild conditions (40 °C stirring) as well as practical scalability.
通过亚甲基氨基酮与对甲苯磺酰叠氮之间的环加成反应，高效地完成了4-酰基-1,2,3-三唑的合成。该方法具有非凡的可持续性，以水作为唯一介质，无需任何催化剂或添加剂，反应条件真正温和（40℃搅拌）且具有实际可扩展性。
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