College of Chemistry and Chemical Engineering, Jiangxi Normal University , Nanchang 330022, P.R. China.
Org Lett. 2016 Dec 2;18(23):6034-6037. doi: 10.1021/acs.orglett.6b02975. Epub 2016 Nov 11.
The domino reactions between NH-based secondary enaminones and tosyl azide have been developed for the synthesis of various N-substituted 1,2,3-triazoles by employing t-BuONa as the base promoter. Through a key Regitz diazo-transfer process with tosyl azide, the reactions proceed efficiently at room temperature with good substrate tolerance.
基于 NH 的仲烯胺酮与对甲苯磺酰基叠氮之间的多米诺反应，在 t-BuONa 作为堿促进剂的条件下，可用于合成各种 N-取代的 1,2,3-三唑。通过与对甲苯磺酰基叠氮的关键 Regitz 重氮转移过程，反应在室温下高效进行，具有良好的底物耐受性。
