Raj Rishi, Jacob Aasems, Venkatanarayan Ajay, Doraiswamy Mohankumar, Ashok Manjula
University of Kentucky, Lexington, KY 40536, USA.
Monmouth Medical Center, Long Branch, NJ 07740, USA.
Case Rep Nephrol. 2018 Sep 5;2018:3697120. doi: 10.1155/2018/3697120. eCollection 2018.
Hyponatremia is a well-known medication related side effect of selective serotonin reuptake inhibitors; despite its association with escitalopram, the newest SSRI is very rare. We did a review of literature and came across only 14 reported case of this rare association of SIADH with escitalopram. We hereby report a case of a 93-year-old female who presented with generalized tonic-clonic seizure and was diagnosed with severe hyponatremia due to escitalopram-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH). With this article, we want to emphasize clinicians about this rare side effect of escitalopram use and look for the risk factors leading to SIADH.
低钠血症是选择性5-羟色胺再摄取抑制剂众所周知的药物相关副作用；尽管它与艾司西酞普兰有关联，但这种最新的选择性5-羟色胺再摄取抑制剂引发低钠血症的情况非常罕见。我们查阅了文献，仅发现14例关于这种罕见的抗利尿激素分泌异常综合征（SIADH）与艾司西酞普兰相关联的报告病例。在此，我们报告一例93岁女性病例，该患者出现全身性强直阵挛性发作，被诊断为因艾司西酞普兰诱发抗利尿激素分泌异常综合征（SIADH）导致的严重低钠血症。通过本文，我们想向临床医生强调使用艾司西酞普兰的这种罕见副作用，并探寻导致抗利尿激素分泌异常综合征（SIADH）的风险因素。
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