RWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, D-52074 Aachen, Germany.
Org Biomol Chem. 2018 Oct 10;16(39):7129-7133. doi: 10.1039/c8ob01991f.
A continuous-flow protocol for the synthesis of diazo acetonitrile was developed. It was further applied in iron-catalysed insertion reactions of diazo acetonitrile into N-H and S-H bonds to yield valuable α-substituted acetonitrile, including gram-scale synthesis.
开发了一种连续流合成重氮乙腈的方法。该方法进一步应用于铁催化的重氮乙腈插入 N-H 和 S-H 键的反应中，得到有价值的α-取代乙腈，包括克级规模的合成。
