Diouf A, Alberici G F, Bidart J M, Bohuon C
J Pharmacol. 1986 Jul-Sep;17(3):254-9.
Among the antimalarial drugs, chloroquine (CLQ) and 4-aminoquinoline derivatives display important interferences with biological membranes. The present study reports the effects of CLQ on dihydropyridine binding sites, measured in the heart of rats intoxicated with the drug. Acute intoxication does not entail any modification of the sites. On the other hand, binding sites were dramatically decreased by a chronic intoxication realized twice a week. In such a case, this decrease may be directly related to CLQ concentration in the heart. The regulation mechanisms involved are discussed.
在抗疟药物中，氯喹（CLQ）和4-氨基喹啉衍生物对生物膜有重要干扰作用。本研究报告了CLQ对二氢吡啶结合位点的影响，该影响是在使用该药物中毒的大鼠心脏中测量的。急性中毒不会导致这些位点发生任何改变。另一方面，每周两次的慢性中毒会使结合位点显著减少。在这种情况下，这种减少可能与心脏中CLQ的浓度直接相关。文中讨论了相关的调节机制。
